| 中文名称: | 阿托伐他汀 | ||||
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| 英文名称: | Atorvastatin | ||||
| 别名: | 阿托他伐汀 (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid;(3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid;Atorvastatin;Atorvastatin Acid;(3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid | ||||
| CAS No: | 134523-00-5 | 分子式: | C33H35FN2O5 | 分子量: | 558.64 |
| CAS No: | 134523-00-5 | ||||
| 分子式: | C33H35FN2O5 | ||||
| 分子量: | 558.64 | ||||
| EINEC: | 7159 | ||||
| EINEC: | 7159 | ||||
基本信息
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产品编号： |
A11321 |
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产品名称： |
Atorvastatin |
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CAS: |
134523-00-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
558.64 |
-20℃ |
一个月 |
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化学名： |
(3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid |
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Solubility (25°C)： |
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体外:
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DMSO |
100mg/mL(179.0mM) |
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Ethanol |
6mg/mL(10.74mM) |
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Water |
Insoluble |
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体内(现配现用): |
1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility:≥2.5mg/mL(4.48mM);Clear solution |
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此⽅案可获得≥2.5mg/mL(4.48mM，饱和度未知)的澄清溶液。以1mL⼯作液为例，取100μL25.0mg/mL的澄清DMSO储备液加到400μL PEG300中，混合均匀；向上述体系中加⼊50μL Tween-80，混合均匀；然后继续加⼊450μL⽣理盐⽔定容⾄1mL。 |
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2.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility:≥2.5mg/mL(4.48mM);Clear solution |
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此⽅案可获得≥2.5mg/mL(4.48mM，饱和度未知)的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以1mL⼯作液为例，取100μL25.0mg/mL的澄清DMSO储备液加到900μL⽟⽶油中，混合均匀。 |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.7901mL |
8.9503mL |
17.9006mL |
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5mM |
0.3580mL |
1.7901mL |
3.5801mL |
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10mM |
0.1790mL |
0.8950mL |
1.7901mL |
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50mM |
0.0358mL |
0.1790mL |
0.3580mL |
生物活性
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产品描述 |
一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。 |
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体外研究 |
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation |
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体内研究 |
Atorvastatin (20-30mg/kg; oral gavage; once a day; for 28 days; ApoE−/− mice) treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang IIinduced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment |
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Animal Model: |
Forty 8-week-old ApoE−/− mice induced with angiotensin II (Ang II) |
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Dosage: |
20mg/kg, 30mg/kg |
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Administration: |
Oral gavage; once a day; for 28 days |
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Result: |
Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE−/− mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
