阿卡地新磷酸盐 - CAS:681006-28-0 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	阿卡地新磷酸盐
英文名称:	AICAR phosphate
别名:	阿卡地新磷酸盐 Acadesine phosphate; AICA Riboside phosphate
CAS No:	681006-28-0	分子式:	C₉H₁₇N₄O₉P	分子量:	356.23
CAS No:	681006-28-0
分子式:	C₉H₁₇N₄O₉P
分子量:	356.23

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A11320 阿卡地新磷酸盐 ≥98% (psaitong)

相关产品

包装规格：

100mg in glass bottle

溶解性：

溶于水（超声）

产品描述：

基本信息

产品编号：A11320
产品名称：AICAR phosphate
CAS:	681006-28-0	储存条件	粉末	-20℃	四年

分子式：	C9H17N4O9P		溶于液体	-80℃	六个月
分子量：	356.23			-20℃	一个月
化学名：
Solubility (25°C)	体外	DMSO
		Ethanol
		Water
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.8072mL	14.0359mL	28.0718mL
5mM	0.5614mL	2.8072mL	5.6143mL
10mM	0.2807mL	1.4036mL	2.8072mL

生物活性

产品描述	一种腺苷类似物，也是一种 AMPK 激活剂。
靶点/IC50	AMPK	Autophagy	Mitophagy
体外研究	HepG2 cells are treated with various concentrations of AICAR (0.1-1.0mM) for 12,24,and 48h,respectively.The expression level of IR-β significantly decreases with 0.25,0.5,and 1.0mM of AICAR at 48h to 50%, 53%,and 46% of the control,respectively.
体内研究	Fourteen-week-old male,lean (L;31.3g body wt) wild-type andob/ob (O;59.6g body wt) mice are injected with the AMP activated kinase (AMPK) activator AICAR (A) at 0.5 mgg body wt-1day-1 or saline control (C) for 14 days.At 24h after the last injection (including a 12-h fast),all mice are killed, and the plantar flexor complex muscle (gastrocnemius,soleus,and plantaris) is excised for analysis.Muscle mass is lower in OC (159±12mg) than LC,LA, and OA (176±10,178±9,and 166±16mg,respectively) mice,independent of a body weight change.The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5mg/g body wt) groups.The heart weight is higher in the exercise group than in the other groups,whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups.

推荐实验方法(仅供参考)

细胞实验:

HepG2 cells (5×105 cells) are plated in 6-well culture plate dishes and then are incubated in the serum-free media for 12h before transfection.One microgram of plasmid is transfected with FuGENE6 Transfection Reagent.After 5h of transfection,the culture media are removed and then media supplemented with or without AICAR (0.1-1.0mM) are added to each well.The stimulation media are changed every 24h.

动物实验:

Rats

Male 5-week-old ZDF rats are either subcutaneously injected with a single dose of AICAR (0.5mg/g body wt) or underwent a single bout of treadmill running (60 min,speed of 25m/min at a 5% incline).Untreated ZDF rats serve as controls (n=5 in each group).One hour after the subcutaneous AICAR injection or immediately after treadmill running,rats are killed by cervical dislocation.To avoid any effect of muscle spasm and hypoxia,red and white gastrocnemius muscles are removed within seconds and immediately freeze clamped for later determination of AMPK activity.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果