中文名称: | Z-Asp-CH2-DCB | ||||
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英文名称: | Z-Asp-CH2-DCB | ||||
别名: | (S)-2,6-dichlorobenzoic Acid 4-Carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl Ester | ||||
CAS No: | 153088-73-4 | 分子式: | C20H17Cl2NO7 | 分子量: | 454.26 |
CAS No: | 153088-73-4 | ||||
分子式: | C20H17Cl2NO7 | ||||
分子量: | 454.26 |
基本信息
产品编号:A11312 |
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产品名称:Z-Asp-CH2-DCB |
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CAS: |
153088-73-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
454.26 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种不可逆的广谱 caspase 抑制剂,Z-Asp-CH2-DCB 也能抑制具有 caspase 样活性的蛋白酶。 |
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靶点/IC50 |
Caspase |
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体外研究 |
Z-Asp-CH2-DCB (10-100μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6,TNF-α, IFN-γ, MCP-1, MIP-1α,and MIP-1β to 10, 36, 25, 10, 11,25,and 30%, respectively, of levels in untreated cells.Z-Asp-CH2-DCB (10-100μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200ng of SEB/ml . Cell Viability Assay |
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Cell Line: |
Human peripheral blood mononuclear cells |
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Concentration: |
10, 50, 100μM |
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Incubation Time: |
48 hours |
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Result: |
Inhibited T-cell proliferation in PBMC stimulated with SEB. |
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体内研究 |
Z-Asp-CH2-DCB (1mg; i.p.;every day for 3 weeks) prevents SU5416-induced septal cell apoptosis. |
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Animal Model: |
Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group) |
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Dosage: |
1mg |
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Administration: |
Intraperitoneal injection; every day for 3weeks |
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Result: |
The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )