| 中文名称: | AGN194204 | ||||
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| 英文名称: | AGN194204 | ||||
| 别名: | IRX4204; NRX194204; VTP 194204 | ||||
| CAS No: | 220619-73-8 | 分子式: | C24H32O2 | 分子量: | 352.51 |
| CAS No: | 220619-73-8 | ||||
| 分子式: | C24H32O2 | ||||
| 分子量: | 352.51 | ||||
基本信息
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产品编号： |
A11301 |
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产品名称： |
AGN194204 |
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CAS: |
220619-73-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
352.51 |
-20℃ |
一个月 |
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化学名： |
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生物活性
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产品描述 |
一种具有口服活性的，选择性RXR激动剂，对RXRα，RXRβ和RXRγ的Kd值分别为0.4nM，3.6nM和3.8nM，EC50分别为0.2nM，0.8nM和0.08nM。 |
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靶点 |
RXRα 0.4nM(Kd) |
RXRβ 3.6nM(Kd) |
RXRγ 3.8nM(Kd) |
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RXRα 0.2nM(EC50) |
RXRβ 0.8nM(EC50) |
RXRγ 0.08nM(EC50) |
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体外研究 |
AGN194204 (NRX194204; 0-100nM; 24 hours; E, RAW cells) treatment blocks the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells. AGN194204 (NRX194204; 1μM; 72 hours; SK-BR-3 human breast cancer cells) treatment induces apoptosis in breast cancer cells Apoptosis Analysis |
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Cell Line: |
SK-BR-3 human breast cancer cells |
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Concentration: |
1μM |
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Incubation Time: |
72 hours |
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Result: |
Induced apoptosis in lung and breast cancer cells. |
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Western Blot Analysis |
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Cell Line: |
E, RAW cells |
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Concentration: |
0nM, 1nM, 10nM and 100nM |
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Incubation Time: |
24 hours |
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Result: |
Blocked the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells. |
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体内研究 |
AGN194204 (NRX194204; 30-60mg/kg; oral administration; daily; for 15 weeks; female A/J mice) treatment significantly reduces the number and size of tumors on the surface of the lungs and reduces the total tumor volume per slide by 64% to 81% compared with the control group |
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Animal Model: |
Female A/J mice with vinyl carbamate |
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Dosage: |
30mg/kg, 60mg/kg |
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Administration: |
Oral administration; daily; for 15 weeks |
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Result: |
Significantly reduced the number and size of tumors on the surface of the lungs and reduced the total tumor volume per slide by 64% to 81% compared with the control group. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
