阿来西定二盐酸盐 - CAS:1715-30-6 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	阿来西定二盐酸盐
英文名称:	Alexidine dihydrochloride
别名:	阿来西定二盐酸盐 Alexidine dihydrochloride
CAS No:	1715-30-6	分子式:	C₂₆H₅₆N₁₀^.₂HCl	分子量:	581.71
CAS No:	1715-30-6
分子式:	C₂₆H₅₆N₁₀^.₂HCl
分子量:	581.71

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

A11069 阿来西定二盐酸盐 ≥98% (psaitong)

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包装规格：

50mg 100mg 250mg in glass bottle

溶解性：

溶于DMSO（250 mg/mL 超声)

产品描述：

基本信息

产品编号：A11069
产品名称：Alexidine dihydrochloride
CAS:	1715-30-6	储存条件	粉末	-20℃	四年
分子式：	C26H56N10.2HCl		溶于液体	-80℃	六个月
分子量	581.71			-20℃	一个月
化学名：	2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(2-ethylhexyl)-3,12-diimino-, dihydrochloride
Solubility (25°C)	体外	DMSO	200mg/mL(343.81mM;Need ultrasonic)
		Ethanol
		Water
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	1.7191mL	8.5953mL	17.1907mL
5mM	0.3438mL	1.7191mL	3.4381mL
10mM	0.1719mL	0.8595mL	1.7191mL

生物活性

产品描述	一种抗癌剂，靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1，并导致线粒体凋亡。
靶点/IC₅₀	PTPMT1
体外研究	Alexidine dihydrochloride displays activity against most Candida spp.; MIC values of ≤1.5μg/mL are observed for all isolates tested under planktonic conditions, with the exception of Candida parapsilosis and Candida krusei. Interestingly, Alexidine dihydrochloride also displays striking activity against clinically relevant fluconazole-resistant Candida isolates: C. albicans (CA2, CA6, and CA10), C. glabrata (CG2 and CG5), C. parapsilosis (CP5), and C. auris (CAU-09 and CAU-03)[1]. Inhibition of planktonic growth by Alexidine dihydrochloride reveals a complete inhibition of filamentation or proliferation of the imaged fungi. Alexidine dihydrochloride is able to decimate at low concentrations (1.5 to 6μg/mL) mature biofilms of Candida, Cryptococcus, and Aspergillus spp. that are known to be resistant to almost all classes of antifungal drugs. In fact, at 10-fold-lower concentrations (150ng/mL) of planktonic MICs, Alexidine dihydrochloride could inhibit lateral yeast formation and biofilm dispersal in C. albicans. Alexidine dihydrochloride results in 50% killing of HUVECs and lung epithelial cells, at concentrations 5- to 10-fold higher than the MIC required to kill planktonically growing fungal pathogens.
体内研究	Chosen to focus on biofilm formation by C. albicans, since a murine biofilm model has been well established in this fungus and used for testing the effects of established and new antifungal agents. The effect of the drugs on the 24-h-old biofilms growing in the jugular vein catheters of mice is visualized microscopically, which reveals significantly lower density of the biofilms in catheters treated with Alexidine dihydrochloride. In fact, fungal CFU determination reveals that Alexidine dihydrochloride inhibits 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果