3-AP - CAS:143621-35-6 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	3-AP 促销
英文名称:	3-AP
别名:	PAN-811 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone
CAS No:	143621-35-6	分子式:	C₇H₉N₅S	分子量:	195.24
CAS No:	143621-35-6
分子式:	C₇H₉N₅S
分子量:	195.24
EINEC:	663249
EINEC:	663249

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A10073 3-AP ≥98%(HPLC) (psaitong)

相关产品

包装规格：

5mg 25mg 100mg in glass bottle

溶解性：

溶于DMSO(≥47mg/mL)

产品描述：

基本信息

产品编号：A10073
产品名称：3-AP
CAS:	143621-35-6	储存条件	粉末	-20℃	四年

分子式：	C7H9N5S		溶于液体	-80℃	六个月
分子量	195.24			-20℃	一个月
化学名：	3-Aminopyridine-2-carboxaldehyde thiosemicarbazone
Solubility (25°C)	体外	DMSO	≥47mg/mL (240.73mM)
		Ethanol
		Water
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	5.1219mL	25.6095mL	51.2190mL
5mM	1.0244mL	5.1219mL	10.2438mL
10mM	0.5122mL	2.5610mL	5.1219mL

生物活性

产品描述	一种具有抗肿瘤活性的核糖核苷酸还原酶抑制剂和铁螯合剂。
靶点/IC₅₀	Ribonucleotide reductase (RR)
体外研究	3-AP (Triapine) is a potent derivative of α-heterocyclic carboxaldehyde thiosemicarbazone (HCT) that inhibits hRRM2 and p53R2 isoforms of the M2 subunit. 3-AP (Triapine) is thought to inhibit ribonucleotide reductase through its preformed iron chelate, rather than directly by removing iron from the active site. In cells containing less topoisomerase IIα fewer DNA strand breaks will be produced, and thus topoisomerase II poisons will be less inhibitory in the K/VP.5 cell line. The IC50s for Dp44mT growth inhibition are 48±9nM and 60±12nM, for K562 and K/VP.5 cells, respectively. The IC50s for 3-AP growth inhibition are 476±39 nM and 661±69 nM for K562 and K/VP.5 cells, respectively. PKIH and DpT Fe chelators show high antiproliferative activity against a range of tumor cell lines. Dp44mT shows the greatest antitumor efficacy with an IC50 that ranged from 0.005 to 0.4μM. The average IC50 of Dp44mT over 28 cell types is 0.03±0.01μM, which is significantly lower than that of 3-AP (Triapine; average IC50: 1.41±0.37μM).
体内研究	3-AP (Triapine) causes a significant increase (1.7-fold) in splenic weight when expressed as a percentage of total body weight(1.02±0.06%; n=25) compared with control mice (0.6±0.03%; n=27). In the long-term group, a significant increase in heart weight is observed after Dp44mT (0.4mg/kg per day) (0.8±0.06%; n=4) compared with control mice (0.5±0.01%; n=6). A significant decrease in the expression of Ndrg1, TfR1, and VEGF1 in the liver is noted for Dp44mT- and 3-AP (12 mg/kg per day)-treated animals. The decreased expression could be related to the increased liver Fe in both Dp44mT- and 3-AP-treated mice.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果