人血管紧张素 II - CAS:4474-91-3 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	人血管紧张素 II 热销
英文名称:	Angiotensin II human
别名:	血管紧张素II Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
CAS No:	4474-91-3	分子式:	C₅₀H₇₁N₁₃O₁₂	分子量:	1046.18
CAS No:	4474-91-3
分子式:	C₅₀H₇₁N₁₃O₁₂
分子量:	1046.18
MDL:	MFCD00161484

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A10051 人血管紧张素 II ≥99% (HPLC) (psaitong)

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外观与性状：

白色粉末

包装规格：

5mg 25mg 100mg in penicillin bottle

溶解性：

acetate：6.3% 溶于水((25 mg/ml)和5%醋酸(1 mg/ml)

产品描述：

基本信息

产品编号：	A10051
产品名称：	Angiotensin II human
CAS:	4474-91-3	储存条件	粉末	-20℃	四年

分子式：	C50H71N13O12		溶于液体	-80℃	六个月
分子量	1046.18			-20℃	一个月
化学名：	Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
Solubility (25°C)：
体外:	DMSO	100mg/mL (95.59mM; Need ultrasonic)
	Ethanol
	Water	50mg/mL (47.79mM; Need ultrasonic)
体内(现配现用):	1.请依序添加每种溶剂：PBS Solubility: 30mg/mL (28.68mM); Clear solution; Need ultrasonic 2.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.5mg/mL (2.39mM); Clear solution
	此⽅案可获得 ≥ 2.5mg/mL (2.39mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。
	3.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility: ≥ 2.5mg/mL (2.39mM); Clear solution
	此⽅案可获得 ≥ 2.5mg/mL (2.39mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中，混合均匀。
	4.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 0.83mg/mL (0.79mM); Clear solution
	此⽅案可获得 ≥ 0.83mg/mL (0.79mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 8.3mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	0.9559mL	4.7793mL	9.5586mL
5mM	0.1912mL	0.9559mL	1.9117mL
10mM	0.0956mL	0.4779mL	0.9559mL

生物活性

产品描述	一种参与调节血压的肽。
靶点	Angiotensin receptor (AT receptor)
体外研究	Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1). Angiotensin II (1nM) induces the expression of LOX-1 and VEGF and enhances capillary formation from human coronary endothelial cells in Matrigel assay. Angiotensin II -mediated expression of LOX-1 and VEGF, capillary formation, intracellular reactive oxygen species generation, and phosphorylation of p38 as well as p44/42 mitogen-activated protein kinases, are suppressed by anti-LOX-1 antibody, nicotinamide-adenine dinucleotide phosphate oxidase inhibitor apocynin and the Ang II type 1 receptor blocker Losartan, but not by the Ang II type 2 receptor blocker PD123319
体内研究	Angiotensin II human (5mL of 1nM; intraperitoneal injection; 200-250 g Sprague-Dawley rats) induces a significant neutrophil recruitment that was maximal at 4 hours and had resolved by 24 hours. To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1000ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption.

推荐实验方法(仅供参考)

Animal Administration

Mice

(129×C57BL/6) F1 mice lacking AT1A receptors for Angiotensin II are used. The mice are fed 10 gm/day gelled 0.25% NaCl diet that contains all nutrients and water. After 1 week of baseline collections, the animals are implanted with osmotic minipumps infusing Angiotensin II and are returned to the metabolic cage for 5 more days. Urinary sodium content is determined by using an IL943 Automatic Flame photometer. After 28 days of Angiotensin II infusion, hearts are harvested, weighed, fixed in formalin, sectioned, and stained with Masson trichrome. All of the tissues are examined by a pathologist (P.R.) without knowledge of genotypes

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果