中文名称: | ANA-12 促销 | ||||
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英文名称: | ANA-12 | ||||
别名: | N-[2-[[(Hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide | ||||
CAS No: | 219766-25-3 | 分子式: | C22H21N3O3S | 分子量: | 407.49 |
CAS No: | 219766-25-3 | ||||
分子式: | C22H21N3O3S | ||||
分子量: | 407.49 | ||||
MDL: | MFCD00117444 |
基本信息
产品编号:A10049 |
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产品名称:ANA-12 |
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CAS: |
219766-25-3 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
407.49 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
37mg/mL warmed with 50ºC water bath (90.79mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用) |
2% DMSO+30% PEG 300+2% Tween 80+ddH2O |
2mg/mL |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.4540mL |
12.2702mL |
24.5405mL |
5mM |
0.4908mL |
2.4540mL |
4.9081mL |
10mM |
0.2454mL |
1.2270mL |
2.4540mL |
50mM |
0.0491mL |
0.2454mL |
0.4908mL |
生物活性
产品描述 |
一种选择性 TrkB 拮抗剂,对高亲和位点和低亲和位点的Kd 分别为10nM 和 12μM。 |
靶点/IC50 |
TrkB |
10nM(Kd) |
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体外研究 |
ANA-12 (10nM) prevents BDNF-induced neurite outgrowth in the TrkB-expressing cells, and completely abolishes the effects of BDNF at concentrations up to 10-100μM. |
体内研究 |
ANA-12 (0.5mg/kg, i.p.) partially inhibits the total endogenous TrkB activity in the whole brain of mice. ANA-12, injected in mice, demonstrates anxiolytic and antidepressive activities at 0.5mg/kg. ANA-12 (0.5,1.0, and 2.0mg/kg) does not affect neuron survival. ANA-12 (0.5mg/kg) shows antidepressant effects in lipopolysaccharide (LPS)-induced depression-like behavior. ANA-12 (0.5mg/kg) significantly attenuates an increased immobility time in depressed mice. In the TST, FST, and SPT, ANA-12 (0.5mg/kg) does not show antidepressant-like effects in the control mice. ANA-12 (0.5mg/kg, i.p.)reverses the diminished self-administration of cocaine in CocSired rats. |
推荐实验方法(仅供参考)
动物实验: |
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On the day of injection, ketamine (ketamine hydrochloride, 10 mg/kg), 7,8-dihydroxyflavone (7,8-DHF; 10mg/kg), and ANA12,N2-(2-{[(2-oxoazepan-3-yl)amino]carbonyl}phenyl)benzo[b]thiophene-2-carboxamide (0.5mg/kg) are prepared in vehicle of 17% dimethyl sulfoxide (DMSO) in phosphate-buffered saline. The doses of ketamine (10mg/kg), 7,8-DHF (10mg/kg), and ANA-12 (0.5mg/kg) are selected. All compounds are administered intraperitoneally (i.p.) to mice. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )