中文名称: | 阿替美唑 促销 | ||||
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英文名称: | Atipamezole | ||||
别名: | 阿替美唑 MPV1248 | ||||
CAS No: | 104054-27-5 | 分子式: | C14H16N2 | 分子量: | 212.29 |
CAS No: | 104054-27-5 | ||||
分子式: | C14H16N2 | ||||
分子量: | 212.29 | ||||
MDL: | MFCD00864502 |
基本信息
产品编号: |
A10032 |
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产品名称: |
Atipamezole |
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CAS: |
104054-27-5 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
212.29 |
-20℃ |
1个月 |
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化学名: |
4-(2-ethyl-2-indanyl)imidazole;4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole |
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Solubility (25°C): |
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体外:
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DMSO |
42mg/mL (197.84mM) |
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Ethanol |
42mg/mL (197.84mM) |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
4.7105mL |
23.5527mL |
47.1054mL |
5mM |
0.9421mL |
4.7105mL |
9.4211mL |
10mM |
0.4711mL |
2.3553mL |
4.7105mL |
50mM |
0.0942mL |
0.4711mL |
0.9421mL |
生物活性
产品描述 |
α2-肾上腺素受体拮抗剂。 |
靶点 |
Ki:1.6nM |
体外研究 |
The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine.Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1,5-HT2 and I2 bindings sites. |
体内研究 |
Atipamezole is well tolerated in rodents.In anesthetized,normotensive rats,the cardiovascular effects of atipamezole (0.01–1mg/kg,i.v.) are rather modest.Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia.Atipamezole increases sexual activity in rats and monkeys.In animals with sustained nociception,atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain.Atipamezole at low doses has beneficial effects on alertness,selective attention,planning,learning,and recall in experimental animals,but not necessarily on short-term working memory. |
推荐实验方法(仅供参考)
动物实验: |
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动物模型 |
Wistar大鼠 |
剂量 |
0.03-3.0mg/kg |
给药处理 |
皮下注射 |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )