2020-10-20

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2: Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ. NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation. Biophys J. 2015 Mar 24;108(6):1400-13. doi: 10.1016/j.bpj.2014.12.055. PubMed PMID: 25809253; PubMed Central PMCID: PMC4375528.

3: Li P, Chen X, Zhang Q, Zheng Y, Jiang H, Yang H, Gao Z. The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels. J Pharmacol Exp Ther. 2014 Dec;351(3):596-604. doi: 10.1124/jpet.114.217703. Epub 2014 Sep 17. PubMed PMID: 25232191.

4: Bilet A, Bauer CK. Effects of the small molecule HERG activator NS1643 on Kv11.3 channels. PLoS One. 2012;7(11):e50886. doi: 10.1371/journal.pone.0050886. Epub 2012 Nov 30. PubMed PMID: 23226420; PubMed Central PMCID: PMC3511382.

5: Durdagi S, Guo J, Lees-Miller JP, Noskov SY, Duff HJ. Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643. J Pharmacol Exp Ther. 2012 Aug;342(2):441-52. doi: 10.1124/jpet.111.189159. Epub 2012 May 9. PubMed PMID: 22573844.

6: Schuster AM, Glassmeier G, Bauer CK. Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells. Mol Pharmacol. 2011 Nov;80(5):930-42. doi: 10.1124/mol.111.071621. Epub 2011 Aug 19. PubMed PMID: 21856740.

7: Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC. Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643. Mol Pharmacol. 2011 Jan;79(1):1-9. doi: 10.1124/mol.110.067728. Epub 2010 Sep 27. PubMed PMID: 20876384; PubMed Central PMCID: PMC3014275.

8: Wu SN, Peng H, Chen BS, Wang YJ, Wu PY, Lin MW. Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells. Mol Pharmacol. 2008 Dec;74(6):1696-704. doi: 10.1124/mol.108.049106. Epub 2008 Sep 22. PubMed PMID: 18809671.

9: Peitersen T, Grunnet M, Benson AP, Holden AV, Holstein-Rathlou NH, Olesen SP. Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model. Heart Rhythm. 2008 May;5(5):734-41. doi: 10.1016/j.hrthm.2008.02.026. Epub 2008 Mar 4. PubMed PMID: 18452879.

10: Xu X, Recanatini M, Roberti M, Tseng GN. Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243). Mol Pharmacol. 2008 Jun;73(6):1709-21. doi: 10.1124/mol.108.045591. Epub 2008 Mar 27. Erratum in: Mol Pharmacol. 2008 Jul;74(1):307. PubMed PMID: 18372399; PubMed Central PMCID: PMC3888322.

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12: Hansen RS, Diness TG, Christ T, Demnitz J, Ravens U, Olesen SP, Grunnet M. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol Pharmacol. 2006 Jan;69(1):266-77. Epub 2005 Oct 11. PubMed PMID: 16219910.