中文名称: | Zoniporide hydrochloride hydrate | ||||
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英文名称: | Zoniporide hydrochloride hydrate | ||||
别名: | Zoniporide hydrochloride hydrate CP-597396hydrochloridehydrate | ||||
CAS No: | 863406-85-3 | 分子式: | C17H19ClN6O2 | 分子量: | 374.82 |
CAS No: | 863406-85-3 | ||||
分子式: | C17H19ClN6O2 | ||||
分子量: | 374.82 |
基本信息
产品编号: |
Z10084 |
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产品名称: |
Zoniporide hydrochloride hydrate |
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CAS: |
863406-85-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
374.82 |
-20℃ |
1个月 |
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化学名: |
5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;hydrate;hydrochloride |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.6679mL |
13.3397mL |
26.6795mL |
5mM |
0.5336mL |
2.6679mL |
5.3359mL |
生物活性
产品描述 |
1型钠氢交换剂(NHE-1)的有效和选择性抑制剂。Zoniporide hydrochloride hydrate抑制人NHE-1(IC50=14nM),与其他NHE亚型相比具有大于150倍的选择性,并有效抑制离体NHE-1依赖性的人血小板溶胀(IC50=59nM)。 |
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靶点 |
IC50:14nM (NHE-1) |
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体内研究 |
Zoniporide hydrochloride hydrate (0.25-4mg/kg;i.v.;every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED50=0.45mg/kg/h) in open chest anesthetized rabbits.Zoniporide exhibits moderate plasma protein binding,has a t1/2 of 1.5 hours in monkeys,and has one major active metabolite.Zoniporide hydrochloride hydrate treatment shows the AUC0-∞and t1/2 are 0.07μg h/mL and 0.5 hours,respectively. |
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Animal Model: |
Rabbit |
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Dosage: |
0.25,1,4mg/kg |
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Administration: |
Every hour for 2 hours;intravenous injection |
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Result: |
Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit.The ED50 was 0.45mg/kg/h. |
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Animal Model: |
Rat |
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Dosage: |
1mg/kg |
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Administration: |
Intravenous injection(Pharmacokinetic Analysis) |
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Result: |
The AUC0-∞and t1/2 were 0.07μg h/mL and 0.5 hours,respectively. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )