扎那米韦 - CAS:139110-80-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	扎那米韦促销
英文名称:	Zanamivir
别名:	扎那米韦 (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
CAS No:	139110-80-8	分子式:	C₁₂H₂₀N₄O₇	分子量:	332.31
CAS No:	139110-80-8
分子式:	C₁₂H₂₀N₄O₇
分子量:	332.31
MDL:	MFCD00866966

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Z10027 扎那米韦 ≥98% (psaitong)

相关产品

包装规格：

25mg 100mg in glass bottle

产品描述：

基本信息

产品编号：Z10027
产品名称：Zanamivir
CAS:	139110-80-8	储存条件	粉末	-20℃	四年

分子式：	C12H20N4O7		溶于液体	-80℃	两年
分子量	332.31			-20℃	一个月
化学名：	5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid
Solubility (25°C)	体外	DMSO	2mg/mL (6.01mM)
		Ethanol	Insoluble
		Water	25mg/mL (75.23mM)
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.0092mL	15.0462mL	30.0924mL
5mM	0.6018mL	3.0092mL	6.0185mL
10mM	0.3009mL	1.5046mL	3.0092mL
50mM	0.0602mL	0.3009mL	0.6018mL

生物活性

产品描述	一种流感病毒的神经氨酸酶抑制剂。
靶点/IC₅₀	neuraminidase
体外研究	Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors,thus preventing release and spread of the newly formed virions.
体内研究	Zanamivir has a poor bioavailability in oral administration, with only 4–17% of the agent. Oral delivery of zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability.

推荐实验方法(仅供参考)

动物实验:

Animal Administration

Rats: Formulations PO-SC (Zanamivir with SC for p.o.) and PO-C (Zanamivir control solution for p.o.) are administered orally at a Zanamivir dose of 10 mg/kg, and IV-R (reference Zanamivir saline solution for i.v.) is administered i.v. at a dose of 1mg/kg to rats under conscious condition. Blood samples are collected prior to and at 0.5, 1, 2, 3, 4, 6, 8, and 24 hr after administration. At each sampling point, three rats from each group are sacrificed after blood collection to extract the lungs.The lungs are cleansed with saline after extraction of lungs from the rats through a chest incision. The lungs are then transferred into E-tube and stored in the freezer (-80°C) until analysis. Plasma samples are harvested by centrifugation at 1,500 × g for 10 min and stored at -20°C until analysis. The analysis of Zanamivir in both plasma and lungs is performed using before-mentioned LC-MS/MS method.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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