中文名称: | Ulixertinib 促销 | ||||
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英文名称: | Ulixertinib | ||||
别名: | (S)-4-(5-氯-2-(异丙胺基)吡啶-4-基)-N-(1-(3-氯苯基)-2-羟乙基)-1H-吡咯-2-甲酰胺 BVD-523 | ||||
CAS No: | 869886-67-9 | 分子式: | C21H22Cl2N4O2 | 分子量: | 433.33 |
CAS No: | 869886-67-9 | ||||
分子式: | C21H22Cl2N4O2 | ||||
分子量: | 433.33 |
一种有效、可口服、高度选择性、ATP-竞争性、可逆、共价的ERK1/2抑制剂。
Ulixertinib is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )