| 中文名称: | TRPC6-IN-1 | ||||
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| 英文名称: | TRPC6-IN-1 | ||||
| 别名: | TRPC6-IN-1 TRPC6-IN-1 | ||||
| CAS No: | 901715-05-7 | 分子式: | C21H23FN4O3 | 分子量: | 398.43 |
| CAS No: | 901715-05-7 | ||||
| 分子式: | C21H23FN4O3 | ||||
| 分子量: | 398.43 | ||||
基本信息
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产品编号： |
T11147 |
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产品名称： |
TRPC6-IN-1 |
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CAS: |
901715-05-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
398.43 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.5099mL |
12.5493mL |
25.0985mL |
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5mM |
0.5020mL |
2.5099mL |
5.0197mL |
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10mM |
0.2510mL |
1.2549mL |
2.5099mL |
生物活性
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产品描述 |
一种TRPC6的抑制剂。 |
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靶点 |
EC50:0.45μM (TRPC3),1.13μM (TRPC7),4.66μM(TRPC3). |
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体外研究 |
TRPC6-IN-1 (compound 4o) rises in the TRPC6 cells in a concentration dependent manner,with a mean EC50 value of 4.66±0.03μM,demonstrating a comparable activity of the compound on TRPC6 as the original lead.TRPC6-IN-1 is also tested on HEK293 cells that co-expressed μ opioid receptor (MOR) and TRPC4β,which belongs to a different subgroup of TRPC channels than TRPC3/6/7.Upon stimulation by a μ agonist,these cells show a robust increase in [Ca2+]i.TRPC6-IN-1 also evokes whole-cell currents in HEK293 cells that express human TRPC3.TRPC6-IN-1 elicits concentration dependent current increases in the TRPC7 cells.Different from TRPC6,the currents show some desensitization in the high TRPC6-IN-1 concentrations (10 and 30μM) at both negative and positive potentials even though the low Ca2+(0.1mM) bath solution is used.Nonetheless,a stepwise increase in the TRPC7 currents is still detected at <10μM TRPC6-IN-1. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
