| 中文名称: | 曲尼司特钠 | ||||
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| 英文名称: | Tranilast sodium | ||||
| 别名: | MK-341 sodium; SB 252218 sodium | ||||
| CAS No: | 104931-56-8 | 分子式: | C18H16NNaO5 | 分子量: | 349.31 |
| CAS No: | 104931-56-8 | ||||
| 分子式: | C18H16NNaO5 | ||||
| 分子量: | 349.31 | ||||
![[4-[(5,6-二苯基吡嗪基)(1-甲基乙基)氨基]丁氧基]乙酸](http:///www.jm-bio.com/content/xtheme/beijingjinming/images/noimage.jpg)
基本信息
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产品编号： |
T10846 |
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产品名称： |
Tranilast sodium |
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CAS: |
104931-56-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量 |
349.31 |
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化学名： |
sodium;2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoate |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种抗变态反应剂。抑制前列腺素 D2 产生 (PGD2，IC50=0.1mM)。具有抗炎和免疫调节作用。Tranilast sodium 拮抗血管紧张素 II (angiotensin II) 并抑制其在血管平滑肌细胞中的生物学作用。 |
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靶点 |
PGD2 0.1mM (IC50) |
Angiotensin II |
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体外研究 |
Tranilast exhibits significant immunomodulatory activity inhibiting Endotoxin-induced prostaglandin E2 (PGE2;IC50=~1-20μM),thromboxane B2 (IC50=~10-50μM),(TGF-β1;IC50=~100-200μM),and IL-8 (IC50=~100μM) formation.A23187-induced monocyte leukotriene C4 or PGE2 formation is inhibited by Tranilast at IC50s of 10-40μM and 2-20μM,respectively.Tranilast (10-200μM) exhibits the anti-proliferative effect in a dose-dependent manner in both MCF-7 and MDA-MB-231 cell lines.Tranilast also (10-200μM) enhances the anti-tumor effects of Tamoxifen (1-20μM) on human breast cancer cells in vitro.Tranilast (12.5,25,50,100μg/mL;72 hours) inhibits proliferation of HDMECs. |
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Cell Line: |
MCF-7 and MDA-MB-231 cells |
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Concentration: |
10,20,50,100,and 200μM |
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Incubation Time: |
48 hours |
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Result: |
Anti-proliferative effect in a dose-dependent manner in both cell lines. |
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Cell Proliferation Assay |
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Cell Line: |
Human dermal microvascular endothelial cells (HDMECs) |
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Concentration: |
12.5,25,50,100μg/mL |
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Incubation Time: |
72 hours |
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Result: |
IC50 value was 44.3μg/mL (136μM). |
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体内研究 |
Tranilast (300mg/kg;administered orally twice a day for 3 days) dose-dependently suppresses angiogenesis in mice. |
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Animal Model: |
Nine-week-old male C57BL/6 mice |
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Dosage: |
300mg/kg |
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Administration: |
Administered orally twice a day for 3 days |
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Result: |
Suppressed the VEGF-induced angiogenesis in matrigel;58% of significant suppression was observed at a dose of 300mg/kg.The ED50 value and 95% confidence limits were 165mg/kg and 162±169mg/kg,respectively. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
