| 中文名称: | Sulindac sulfide | ||||
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| 英文名称: | Sulindac sulfide | ||||
| 别名: | 5-氟-2-甲基-1-(4-甲硫基亚苄基)茚-3-乙酸;硫化舒林酸;舒林酸相关化合物C USP标准品 (Z)-2-(5-Fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetic acid | ||||
| CAS No: | 49627-27-2 | 分子式: | C20H17FO2S | 分子量: | 340.41 |
| CAS No: | 49627-27-2 | ||||
| 分子式: | C20H17FO2S | ||||
| 分子量: | 340.41 | ||||
基本信息
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产品编号： |
S70051 |
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产品名称： |
Sulindac sulfide |
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CAS: |
49627-27-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量 |
340.41 |
-20℃ |
1个月 |
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化学名： |
(Z)-2-(5-Fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetic acid |
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Solubility (25°C)： |
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体外:
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DMSO |
50 mg/mL (146.88mM; Need ultrasonic) |
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Ethanol |
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Water |
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体内(现配现用): |
1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.5 mg/mL (7.34mM); Clear solution |
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此方案可获得 ≥ 2.5 mg/mL (7.34mM，饱和度未知) 的澄清溶液。 以 1mL 工作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加入50μL Tween-80，混合均匀；然后继续加入 450μL生理盐水定容至 1mL。 |
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2.请依序添加每种溶剂： 10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (7.34mM); Clear solution |
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此方案可获得 ≥ 2.5 mg/mL (7.34mM，饱和度未知) 的澄清溶液。 以 1mL 工作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。 |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.9376mL |
14.6882mL |
29.3763mL |
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5mM |
0.5875mL |
2.9376mL |
5.8753mL |
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10mM |
0.2938mL |
1.4688mL |
2.9376mL |
生物活性
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产品描述 |
γ-secretase 的一种非竞争性抑制剂。 |
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靶点 |
IC50: 20.2μM (γ42-secretase). |
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体外研究 |
Treatment with 100μM of Sulindac sulfide (SSide) causes cell death presumably by inducing apoptosis, resulting in marked decrease in Aβgeneration as well as in total protein expression. The IC50 value for Aβ42 secretion of Sulindac sulfide is 30.6±2.8μM. SSone and naproxen have no effect either on Aβ40 or Aβ42 secretion as well as on Notch cleavage up to 100μM. It is observed that an inhibition of γ42-secretase activity by Sulindac sulfide in a dose-dependent manner. The IC50 value of SSide for inhibiting γ42-secretase activity in vitro is 20.2±2.6μM. A decrease is found in slope by the increase of the concentration of SSide in the plot of rate against the enzyme concentration, suggesting that Sulindac sulfide is not an irreversible or pseudo-irreversible inhibitor. Moreover, when the dialyzed solubilizedγ-secretase fraction is pretreated with Sulindac sulfide against CHAPSO buffer without Sulindac sulfide, γ-secretase activity is almost totally recovered. From these data, it is strongly suggested that the genuine molecular target of Sulindac sulfide is the γ-secretase complex and that Sulindac sulfide works as a reversible γ-secretase inhibitor. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
