中文名称: | SAICAR | ||||
---|---|---|---|---|---|
英文名称: | SAICAR | ||||
别名: | 5-Amino-4-imidazole-N-succinocarboxamide ribonucleotide | ||||
CAS No: | 3031-95-6 | 分子式: | C13H19N4O12P | 分子量: | 454.28 |
CAS No: | 3031-95-6 | ||||
分子式: | C13H19N4O12P | ||||
分子量: | 454.28 |
嘌呤核苷酸从头合成的中间体,以同工酶选择性性方式激活 PKM2,EC50 为 0.3 mM。SAICAR 刺激 PKM2 并促进癌细胞在葡萄糖限制条件下的存活。
SAICAR, also known as Succino-AICAR, is an intermediate in the de novo purine nucleotide synthesis pathway. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )