中文名称: | SKF 83959 hydrobromide | ||||
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英文名称: | SKF 83959 hydrobromide | ||||
别名: | 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide | ||||
CAS No: | 67287-95-0 | 分子式: | C18H21BrClNO2 | 分子量: | 398.72 |
CAS No: | 67287-95-0 | ||||
分子式: | C18H21BrClNO2 | ||||
分子量: | 398.72 |
基本信息
产品编号: |
S11172 |
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产品名称: |
SKF 83959 hydrobromide |
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CAS: |
67287-95-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
398.72 |
-20℃ |
1个月 |
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化学名: |
6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.5080mL |
12.5401mL |
25.0803mL |
5mM |
0.5016mL |
2.5080mL |
5.0161mL |
10mM |
0.2508mL |
1.2540mL |
2.5080mL |
生物活性
产品描述 |
一种有效的选择性多巴胺 D1 类受体部分激动剂。 |
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靶点 |
Dopamine Receptor |
Sigma Receptor |
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体外研究 |
SKF83959 hydrobromide (10~250μM) stimulates PIP2 hydrolysis in membranes.SKF83959 hydrobromide (0.1~10μM;PC12 cell) changes the EC50 value of SKF81297 from 0.5nM in control tissue to 31.6nM,251.2nM and 631.0nM. |
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体内研究 |
SKF83959 hydrobromide (0.5 and 1mg/kg;i.p.;1 hour) reverses the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.SKF83959 hydrobromide (1mg/kg;i.p.;30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade.SKF83959 hydrobromide has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice. |
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Animal Model: |
Male ICR male mice (8 weeks) |
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Dosage: |
0.5 and 1mg/kg |
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Administration: |
I.p.;1 hour |
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Result: |
Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test. |
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Animal Model: |
Male ICR male mice (8 weeks) |
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Dosage: |
1mg/kg |
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Administration: |
I.p.;30 minutes |
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Result: |
The memory enhancing effects were prevented by BDNF system blockade. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )