中文名称: | STAT5-IN-1 | ||||
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英文名称: | STAT5-IN-1 | ||||
别名: | STAT5-IN-1 STAT5-IN-1 | ||||
CAS No: | 285986-31-4 | 分子式: | C16H11N3O3 | 分子量: | 293.28 |
CAS No: | 285986-31-4 | ||||
分子式: | C16H11N3O3 | ||||
分子量: | 293.28 |
基本信息
产品编号: |
S10924 |
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产品名称: |
STAT5-IN-1 |
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CAS: |
285986-31-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
293.28 |
-20℃ |
1个月 |
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化学名: |
N-[(E)-(4-oxochromen-3-yl)methylideneamino]pyridine-3-carboxamide |
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Solubility (25°C): |
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体外:
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DMSO |
20mg/mL (68.19mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.4097mL |
17.0486mL |
34.0971mL |
5mM |
0.6819mL |
3.4097mL |
6.8194mL |
10mM |
0.3410mL |
1.7049mL |
3.4097mL |
50mM |
0.0682mL |
0.3410mL |
0.6819mL |
生物活性
产品描述 |
一种STAT5的抑制剂,对STAT5β亚型的IC50值为47μM。 |
靶点 |
STAT5β |
47μM |
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体外研究 |
The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins,implicated in cell growth and differentiation.STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain.The functions of the SH2 domains of STAT3,STAT1,and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500µM).STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts.Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β,but leads to complete loss of selectivity against other STAT family members. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )