| 中文名称: | SCH23390 HCL 促销 | ||||
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| 英文名称: | SCH23390 HCL | ||||
| 别名: | SCH23390 HCL (R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride | ||||
| CAS No: | 125941-87-9 | 分子式: | C17H18ClNO.HCl | 分子量: | 324.24 |
| CAS No: | 125941-87-9 | ||||
| 分子式: | C17H18ClNO.HCl | ||||
| 分子量: | 324.24 | ||||
| MDL: | MFCD00069249 | ||||
基本信息
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产品编号： |
S10501 |
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产品名称： |
SCH23390 HCL |
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CAS: |
125941-87-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
324.24 |
-20℃ |
1个月 |
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化学名： |
(R)-8-氯-2,3,4,5-四氢-3-甲基-5-苯基-1H-3-苯并氮杂卓-7-醇盐酸盐(R)-2,3,4,5-Tetrahydro-8-chloro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
65mg/mL (200.46mM) |
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Ethanol |
25mg/mL (77.1mM) |
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Water |
20mg/mL (61.68mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.0841mL |
15.4207mL |
30.8414mL |
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5mM |
0.6168mL |
3.0841mL |
6.1683mL |
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10mM |
0.3084mL |
1.5421mL |
3.0841mL |
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50mM |
0.0617mL |
0.3084mL |
0.6168mL |
生物活性
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产品描述 |
一种有效的选择性的多巴胺D1样受体拮抗剂。 |
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靶点 |
Dopamine Receptor |
5-HT Receptor |
Potassium Channel |
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体外研究 |
SCH-23390 (1μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase1 and IL-1β in the LPS-induced BV-2 cells.SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants.SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated,such as psychosis and Parkinson's disease.Apart from the study of neurological disorders,SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents,nonhuman primates,and humans.SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3mg/kg i.p.in the rat.SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions. |
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体内研究 |
SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants.SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated,such as psychosis and Parkinson's disease.Apart from the study of neurological disorders,SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents,nonhuman primates, and humans.SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3mg/kg i.p.in the rat.SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions. |
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推荐实验方法(仅供参考)
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Rats: All rats receive acclimatization saline injections the two afternoons 1 prior to 2 their test day.At the end of the Training phase,rats (n=15 or 16 rats/group) are assigned to one 3 of three conditions (0,1,or 10μg/kg IP injections of SCH 23390).The day following the Training phase,rats are tested in the operant 6 conditioning chambers for saccharin cue-reactivity (saccharin seeking). |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
