中文名称: Rilmazafone hydrochloride
英文名称: Rilmazafone hydrochloride
CAS No: 85815-37-8
分子式: C21H21Cl3N6O3
分子量: 511.79
R10370 Rilmazafone hydrochloride (psaitong)
包装规格:
1mg in glass bottle
产品描述:

基本信息

产品编号:

R10370

产品名称:

Rilmazafone hydrochloride

CAS:

85815-37-8

 

储存条件

粉末

-20℃

四年

分子式:

C21H21Cl3N6O3

溶于液体

-80℃

二年

分子量:

511.79

 

 

化学名: 

5-[[(2-aminoacetyl)amino]methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1,2,4-triazole-3-carboxamide;hydrochloride

Solubility (25°C):

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

生物活性

产品描述

一种苯二氮卓类ω配体,具有镇静和催眠作用。

靶点

GABA Receptor

体内研究

When the animals are pretreated with high doses of Rilmazafone hydrochloride (450191-S;200 or 600mg/kg for 5 or 3 days,respectively) to induce hepatic drug-metabolizing enzymes,plasma concentrations of the metabolites after oral administration of a dose of 200mg/kg of Rilmazafone decrease markedly depending on the induced enzyme activity.Pretreatment of rats with phenobarbital also causes decreased plasma levels of metabolites,which are almost the same as those in Rilmazafone-pretreatment.On the other hand,administration of beta-naphthoflavone to rats leads to higher plasma levels of metabolites,and slower elimination compared with those in the control and Rilmazafone or Phenobarbital pretreated rats.Rilmazafone is demonstrated to stimulate the hepatic drug-metabolizing enzymes in rats, mice and dogs,which is accompanied by a marked reduction in the pharmacological activity of pentobarbital in rats.The induction of hepatic enzyme activities by Rilmazafone is detected only when the plasma concentrations of its metabolites are very high.

 

推荐实验方法(仅供参考)

动物实验:

 

Mice

Adult male rats of the Jcl Sprague-Dawley strain,7-8 weeks old,are used for the experiments.The animals are kept in an airconditioned room (25±1℃,50-60% humidity) lighted 12hr a day (8:00-20:00) and maintain on com mercial rat chow and water ad libitum.Rilmazafone is dissolved in 5% (w/v) arabic gum at 20 or 60mg/mL,and the resulting solution is administered orally to rats at 1.0mL/100g body weight for 3-5 days.Typical inducers,phenobarbital (in physiological saline) and beta-naphthoflavone (in sesame oil),are administered intraperitoneally at a dose of 40mg/kg,once daily for 3 days.The animals are fasted for 24hr after the last adminis tration of Rilmazafone or inducers,and then the test solution of Rilmazafone (20mg/mL of 5% arabic gum) is given orally to rats at a dose of 200mg/kg.Heparinized blood samples are obtained from the abdominal aorta under ether anesthesia and centrifuged immediately to obtain plasma samples using an Eppendorf centrifuge Type 5414S. 

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

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用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):