中文名称: RO-9187
英文名称: RO-9187
CAS No: 876708-03-1
分子式: C9H12N6O5
分子量: 284.23
R10205 RO-9187 ≥98% (psaitong)
包装规格:
10mg in glass bottle
产品描述:

基本信息

产品编号:R10205

产品名称:RO-9187

CAS:

876708-03-1

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C9H12N6O5

溶于液体

-80℃

六个月

分子量

284.23

-20℃

一个月

化学名: 

4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

 

Solubility (25°C)

 

体外

DMSO

 

Ethanol

 

Water

7mg/mL (24.63mM; Need ultrasonic)

体内

现配现用

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

3.5183mL

17.5914mL

35.1828mL

5mM

0.7037mL

3.5183mL

7.0366mL

10mM

0.3518mL

1.7591mL

3.5183mL

 

生物活性

产品描述

一种高效的HCV病毒复制抑制剂,IC50值为171nM。

靶点/IC50

HCV

IC50: 171nM

 

体外研究

RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-Cmethyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12μM RO9187

 

体内研究

Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing.Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level,respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.

 

推荐实验方法(仅供参考)

动物实验:

 

Animal Administration

Rats: A 2-week oral range finding toxicity study is performed with RO-9187 and ribavirin in Hanover-Wistar rats. Five male and five female rats in each of five treatment groups are administered once daily doses of vehicle, 200, 600, or 2000mg/kg RO-9187 or 200mg/kg ribavirin by oral gavage for 14 days.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):