中文名称: | RO-9187 | ||||
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英文名称: | RO-9187 | ||||
别名: | 4-氨基-1-(4-C-叠氮基-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮 RO 9187;RO-9187 | ||||
CAS No: | 876708-03-1 | 分子式: | C9H12N6O5 | 分子量: | 284.23 |
CAS No: | 876708-03-1 | ||||
分子式: | C9H12N6O5 | ||||
分子量: | 284.23 |
基本信息
产品编号:R10205 |
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产品名称:RO-9187 |
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CAS: |
876708-03-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
284.23 |
-20℃ |
一个月 |
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化学名: |
4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
7mg/mL (24.63mM; Need ultrasonic) |
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体内 |
现配现用 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.5183mL |
17.5914mL |
35.1828mL |
5mM |
0.7037mL |
3.5183mL |
7.0366mL |
10mM |
0.3518mL |
1.7591mL |
3.5183mL |
生物活性
产品描述 |
一种高效的HCV病毒复制抑制剂,IC50值为171nM。 |
靶点/IC50 |
HCV IC50: 171nM |
体外研究 |
RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-Cmethyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12μM RO9187 |
体内研究 |
Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing.Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level,respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day. |
推荐实验方法(仅供参考)
动物实验: |
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Animal Administration |
Rats: A 2-week oral range finding toxicity study is performed with RO-9187 and ribavirin in Hanover-Wistar rats. Five male and five female rats in each of five treatment groups are administered once daily doses of vehicle, 200, 600, or 2000mg/kg RO-9187 or 200mg/kg ribavirin by oral gavage for 14 days. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )