中文名称: Rostafuroxin
英文名称: Rostafuroxin
CAS No: 156722-18-8
分子式: C23H34O4
分子量: 374.52
R10157 Rostafuroxin ≥98% (psaitong)
包装规格:
5mg 25mg 100mg in glass bottle
溶解性:
溶于DMSO(≥50mg/mL )
产品描述:

基本信息

产品编号:

R10157

产品名称:

Rostafuroxin

CAS:

156722-18-8

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C23H34O4

溶于液体

-80℃

6个月

分子量:

374.52

-20℃

1个月

化学名: 

3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethylhexadecahydro-14H-cyclopenta[a]phenanthrene-3,14,17-triol

Solubility (25°C):

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

2.6702mL

13.3508mL

26.7016mL

5mM

0.5340mL

2.6702mL

5.3403mL

10mM

0.2670mL

1.3351mL

2.6702mL

 

生物活性

产品描述

一种Na+K ATPase拮抗剂。

靶点

Na+/K+ATPase;RSV

 

体外研究

Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling.Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced,Src-dependent Na+,K+-ATPase phosphorylation and activation.Rostafuroxin (0.125-128μM;for 24h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC.Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC50=1.8μM) and A549 cells (IC50=14.8μM).Rostafuroxin displaced [3H]Ouabain from the dog kidney Na+,K+-ATPase receptor (IC50=1.5nM),is devoid of cardiac inotropic activity in isolated guinea pig atria,and shows no affinity up to 10-4 M with general (R1,R2,a1,a2,A1,A2,M1,M2,H1,H2,5-HT1,5-HT2,Ca2+ channels,TXA2/PGH2,PAF,GABAA,GABAB,DA-NE-5-HT uptake,glutammate,glycine,benzodiazepine) and hormonal (estrogenic,progestinic,androgenic,mineralcorticoid) receptors.

体内研究

Rostafuroxin (PST 2238;1mg/kg/day;gavage;for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation.

Animal Model:

Male 7-week-old Wistar rats

Dosage:

1mg/kg

Administration:

Gavage;daily;for 3 weeks

Result:

Decreased SBP,improved acetylcholine-induced relaxation via enhanced nitric oxide synthesis and bioavailability,decreased superoxide anion generation from NAD(P)H oxidase and cyclooxygenase-2 and reduced cytoplasmic tyrosine kinase Src phosphorylation.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):