| 中文名称: | 泮托拉唑钠水合物 | ||||
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| 英文名称: | Pantoprazole sodium hydrate | ||||
| 别名: | 泮托拉唑钠水合物 disodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;trihydrate | ||||
| CAS No: | 164579-32-2 | 分子式: | C16H14F2N3NaO4S.XH2O | 分子量: | 432.37 |
| CAS No: | 164579-32-2 | ||||
| 分子式: | C16H14F2N3NaO4S.XH2O | ||||
| 分子量: | 432.37 | ||||
基本信息
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产品编号： |
P10828 |
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产品名称： |
Pantoprazole sodium hydrate |
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CAS: |
164579-32-2 |
储存条件 |
粉末 |
2-8℃(避光) |
四年 |
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分子式： |
溶于液体 |
-80℃(避光) |
6个月 |
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分子量： |
432.37 |
-20℃(避光) |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
100mg/mL (115.64mM) |
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Ethanol |
100mg/mL (115.64mM) |
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Water |
17mg/mL (19.65mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.1564mL |
5.7820mL |
11.5640mL |
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5mM |
0.2313mL |
1.1564mL |
2.3128mL |
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10mM |
0.1156mL |
0.5782mL |
1.1564mL |
生物活性
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产品描述 |
一种具有口服活性的，有效质子泵(proton pump)抑制剂(PPI)。 |
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靶点 |
Proton Pump |
Autophagy |
Apoptosis |
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体外研究 |
Pantoprazole sodium hydrate (BY1023 sodium hydrate;1-10000μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells.Pantoprazole sodium hydrate can block exosome release.Pantoprazole sodium hydrate inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas,adenocarcinomas,and lymphoma cell lines) to acidify the extracellular medium. |
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体内研究 |
Pantoprazole sodium hydrate (BY1023 sodium hydrate;200mg/kg;IP;once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.Pantoprazole sodium hydrate (0.3-3mg/kg,p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats. |
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Animal Model: |
Mice bearing MCF-7 or A431 xenografts |
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Dosage: |
200 mg/kg |
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Administration: |
IP;once a week for 3 weeks;alone or 2 hours before Doxorubicin (6mg/kg i.v.) |
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Result: |
Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination.Significantly increased tumor growth delay with a single dose with Doxorubicin.There is no effect on growth delay alone. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
