| 中文名称: | 喷他脒 促销 | ||||
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| 英文名称: | Pentamidine | ||||
| 别名: | 喷它咪；戊烷脒；戊脘脒 MP-601205 | ||||
| CAS No: | 100-33-4 | 分子式: | C19H24N4O2 | 分子量: | 340.42 |
| CAS No: | 100-33-4 | ||||
| 分子式: | C19H24N4O2 | ||||
| 分子量: | 340.42 | ||||
| MDL: | MFCD00599574 | EINEC: | 202-841-0 | ||
| EINEC: | 202-841-0 | ||||
基本信息
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产品编号：P10702 |
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产品名称：Pentamidine |
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CAS: |
100-33-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
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分子量 |
340.42 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内 |
现配现用 |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种抗微生物剂，会干扰 DNA 的生物合成。 |
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靶点/IC50 |
Leishmania infantum
IC50: 2.5μM |
Protein tyrosine phosphatases (PTPases) |
Phosphatase of regenerating liver (PRL) |
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体外研究 |
Pentamidine (0-10µg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner. The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite Leishmania infantum is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin,which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein. Cell Viability Assay |
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Cell Line |
WM9, DU145, C4-2, Hey, WM480, and A549 cells |
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Concentration: |
0-10 µg/m |
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Incubation Time |
6 days |
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Result: |
The growth of all six of the cell lines in culture was inhibited in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10µg/mL. |
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体内研究 |
Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice |
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Animal Model: |
Athymic nude mice (6 weeks old) injected with WM9 cells |
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Dosage: |
0.25mg/mouse |
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Administration: |
Intramuscular injection; every 2 days; for 4 weeks |
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Result: |
Markedly inhibited the growth of WM9 human melanoma tumors in nude mice. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
