中文名称: | P22077 | ||||
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英文名称: | P22077 | ||||
别名: | 1-[5-[(2,4-二氟苯基)硫基]-4-硝基-2-噻吩基]乙酮;P 22077 抑制剂 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone | ||||
CAS No: | 1247819-59-5 | 分子式: | C12H7F2NO3S2 | 分子量: | 315.31 |
CAS No: | 1247819-59-5 | ||||
分子式: | C12H7F2NO3S2 | ||||
分子量: | 315.31 |
一种泛素蛋白特异性蛋白酶(USP7)抑制剂。
P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P22077 also significantly augmented the cytotoxic effects of doxorubicin (Dox) and etoposide (VP-16) in NB cells with an intact USP7-HDM2-p53 axis. Moreover, P22077 was found to be able to sensitize chemoresistant LA-N-6 NB cells to chemotherapy. In an in vivo orthotopic NB mouse model, P22077 significantly inhibited the xenograft growth of three NB cell lines. USP7-specific inhibitors like P22077 may serve not only as a stand-alone therapy but also as an effective adjunct to current chemotherapeutic regimens for treating NB with an intact USP7-HDM2-p53 axis.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )