中文名称: Piclidenoson
英文名称: b-D-Ribofuranuronamide,1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-
CAS No: 152918-18-8
分子式: C18H19In6O4
分子量: 510.28
P10152 Piclidenoson ≥98%(HPLC) (psaitong)
包装规格:
1mg 5mg 25mg 100mg in glass bottle
溶解性:
溶于DMSO(>5mg/mL)和乙醇(>10mg/mL 加热)。
产品描述:

基本信息

产品编号:

P10152

产品名称:

b-D-Ribofuranuronamide,1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-

CAS:

152918-18-8

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C18H19In6O4

溶于液体

-80℃

6个月

分子量:

510.28

-20℃

1个月

化学名: 

(2S,3S,4R,5R)-3,4-dihydroxy-5-(6-((3-iodobenzyl)amino)-9H-purin-9-yl)-N-methyltetrahydrofuran-2-carboxamide

Solubility (25°C):

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

1.9597mL

9.7983mL

19.5967mL

5mM

0.3919mL

1.9597mL

3.9193mL

10mM

0.1960mL

0.9798mL

1.9597mL

 

生物活性

产品描述

一种腺苷A3受体激动剂, EC50值为0.11μM。

靶点

A3AR

 

体外研究

Piclidenoson is able to inhibit Forskolin (HY-15371)-stimulated cAMP levels with EC50s of 0.82μM and 1.2μM in OVCAR-3 cells and Caov-4 cells,respectively.Piclidenoson (0.0001-100μM;48 hours) significantly reduces cell viability in a dose-dependent manner in human ovarian cancer cell lines,with IC50s of 32.14μM and 45.37μM for OVCAR-3 and Caov-4 cells,respectively.Piclidenoson (0.001-100μM;48 hours) induces apoptosis in ovarian cancer cell line through the caspase pathway.Piclidenoson induces apoptosis via the mitochondrial signaling pathway.

Cell Proliferation Assay

Cell Line:

OVCAR-3 cells,Caov-4 cells

Concentration:

Concentration:0.0001-100μM

Incubation Time:

48 hours

Result:

Resulted in a dose-dependent reduction in the cell viability.

Apoptosis Analysis

Cell Line:

OVCAR-3 cells, Caov-4 cells

Concentration:

0.1μM,1μM,10μM,50μM,100μM

Incubation Time:

48 hours

Result:

Significant increased in the percentage of apoptosis in a concentration-dependent manner.

Western Blot Analysis

Cell Line:

OVCAR-3 cells, Caov-4 cells

Concentration:

1μM,10μM,100μM

Incubation Time:

48 hours

Result:

Decreased the expression of Bcl-2 was noticeably and increased the expression of Bax protein.

体内研究

Piclidenoson (105μg/kg;i.p.) enhances survival of γ-irradiated mice.

Animal Model:

B10CBAF1 male mice aged 3 months (average 30g)

Dosage:

105μg/kg

Administration:

Intraperitoneal injection, 0.5h after irradiation

Result:

Resulted in statistically significant increases of the mean survival time in comparison with the control irradiated mice.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):