中文名称: | OPC-14523 hydrochloride | ||||
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英文名称: | OPC-14523 hydrochloride | ||||
CAS No: | 145969-31-9 | 分子式: | C23H29Cl2N3O2 | 分子量: | 450.4 |
CAS No: | 145969-31-9 | ||||
分子式: | C23H29Cl2N3O2 | ||||
分子量: | 450.4 |
基本信息
产品编号: |
O10239 |
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产品名称: |
OPC-14523 hydrochloride |
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CAS: |
145969-31-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
450.40 |
-20℃ |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.2202mL |
11.1012mL |
22.2025mL |
5mM |
0.4440mL |
2.2202mL |
4.4405mL |
10mM |
0.2220mL |
1.1101mL |
2.2202mL |
生物活性
产品描述 |
一种具有口服活性的 sigma 和 5-HT1A 受体激动剂,对 sigma 受体 (σ1/2 IC50=47/56nM)、5-HT1A 受体 (IC50=2.3nM) 和 5-HT 转运体 (IC50=80nM) 具有高度亲和力。 |
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靶点 |
HT1A Receptor 2.3nM (IC50) |
sigma 1 47nM (IC50) |
sigma 2 56mM (IC50) |
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体外研究 |
OPC-14523 hydrochloride inhibits the in vitro reuptake of 3 H-5-HT (IC50=27nM),but it shows very weak inhibitory activity on 3H-NE and 3H-DA reuptake. |
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体内研究 |
OPC-14523 hydrochloride (0.3-100mg/kg;p.o.;daily for 0,2,4,7 days) produces a marked antidepressant-like effect in the forced swimming test (FST) with rats and mice without affecting the general locomotor activity. |
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Animal Model: |
Wistar strain of rats (140-245g) |
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Dosage: |
0.3-100mg/kg |
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Administration: |
P.o;daily for 0,2,4,7 days |
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Result: |
A single doses of 1 mg/kg and higher of OPC-14523 reduced immobility time in the FST with an ED50 value of 27mg/kg.The ED50 value for OPC-14523 on day 7 was 18mg/kg. |
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Animal Model: |
ICR strain of mice (25-45g) |
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Dosage: |
0.3-100 mg/kg |
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Administration: |
P.o;daily for 0,2,4,7 days |
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Result: |
A single oral dose of OPC-14523 produced a marked reduction in immobility time during the FST at oral doses of 1mg/kg and higher,with an ED50 value of 20mg/kg.The potency of OPC-14523 in decreasing immobility time was greater after treatment for seven consecutive days,producing an ED50 value of 2mg/kg. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )