中文名称: OR-1896
英文名称: OR-1896
CAS No: 220246-81-1
分子式: C13H15N3O2
分子量: 245.28
O10212 OR-1896 ≥98% (psaitong)
包装规格:
5mg 10mg 25mg in glass bottle
溶解性:
溶于DMSO(62.5 mg/mL 超声)
产品描述:

基本信息

产品编号:

O10212

产品名称:

OR-1896

CAS:

220246-81-1

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C13H15N3O2

溶于液体

-80℃

6个月

分子量:

245.28

-20℃

1个月

化学名: 

(R)-N-ACETYL-6-(4-AMINOPHENYL)-4,5-DIHYDRO-5-METHYL-3(2H)-PYRIDAZINONE

Solubility (25°C):

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

4.0770mL

20.3849mL

40.7697mL

5mM

0.8154mL

4.0770mL

8.1539mL

10mM

0.4077mL

2.0385mL

4.0770mL

 

生物活性

产品描述

一种高选择性磷酸二酯酶(PDE III)抑制剂,是一种功能强大的血管扩张剂。OR-1896可以打开ATP敏感的K+通道,并具有Ca2+致敏作用。

靶点

PDE3/PDE Ⅲ

K+ Channel

Drug Metabolite

 

体外研究

There are many evidences has accumulated and revealed a variety of beneficial pleiotropic effects OR-1896.OR-1896 evokes prominent vasodilatory responses,activation of ATP-sensitive sarcolemmal K+channels of smooth muscle cells appears as a powerful vasodilator mechanism.Additionally,activation of ATP-sensitive K+channels in the mitochondria potentially extends the range of cellular actions towards the modulation of mitochondrial ATP production and implicates a pharmacological mechanism for cardioprotection.

体内研究

During the metabolism of Levosimendan approximately 5% of the drug is converted to the metabolite OR-1855 in the large intestine,and then acetylated in the liver to form the active metabolite OR-1896.Binding to plasma proteins is 98% for Levosimendan but only 40% for OR-1896.Unlike Levosimendan,which has an elimination half-life of 1-1.5h,the half-life of OR-1896 is about 75 to 80h allowing cardiovascular effects to persist up to 7 to 9 days after discontinuation of a 24-hour infusion of levosimendan.The pharmacokinetic of the parent drug is unaltered in subjects with severe renal impairment or with moderate hepatic impairment,whereas the elimination of its metabolites (OR-1896) can be prolonged.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):