中文名称: | L-4-噁溶菌素盐酸盐 | ||||
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英文名称: | L-4-Oxalysine hydrochloride | ||||
别名: | L-4-噁溶菌素盐酸盐 L-4-Oxalysine hydrochloride | ||||
CAS No: | 118021-35-5 | 分子式: | C5H13ClN2O3 | 分子量: | 184.62 |
CAS No: | 118021-35-5 | ||||
分子式: | C5H13ClN2O3 | ||||
分子量: | 184.62 |
基本信息
产品编号:O10182 |
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产品名称:L-4-Oxalysine hydrochloride |
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CAS: |
118021-35-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
184.62 |
-20℃ |
一个月 |
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化学名: |
(S)-(+)-2-Amino-3-(2-aminoethoxy)propanoic acid monohydrochloride |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内 |
现配现用 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
从中国的链霉菌培养基中分离的天然物质,具有抗癌活性。 |
靶点/IC50 |
Fungal |
体外研究 |
Alpha-fetoprotein (AFP) is expressed in BEL-7404 human hepatoma cells and L-4-Oxalysine suppresses AFP mRNA expression in the cells. L-4-oxalysine functionally antagonizes the a-fetoprotein-induced suppression of the mitogen- and one-way mixed lymphocyte culture-induced proliferation of spleen lymphocytes and interleukin-6 production by these cells in mice bearing the hepatoma-22 tumor. |
体内研究 |
Tbe ultrastructural efects of different doses of L-4-Oxalysine on hepatocytes in mice are most serious at day 1 after stoppintreatment. Mice are given ig L-4-oxalysine (I-677) 10, 50, and 100mg/kg for 7 d. On day 8 the hepatocytes show accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets is far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER is only found in the groups of medium and high dose. L-4- oxalysine inhibits the proliferation of some mouse implanted tumors and pulmonary metastasis of mouse Lewis lung carcinoma |
推荐实验方法(仅供参考)
动物实验: |
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Animal Administration |
Mice: Sixty mice are randomly and equally divided into 4 groups. One of the groups is given ig saline and the other are given ig 10, 50, 100mg /kg for 7d. On day l, 7, 14, and 28 respectively after terminating the treatment, 3 mice of each group are killed and the samples are examined under transmission electron microscope. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )