中文名称: | Olafertinib | ||||
---|---|---|---|---|---|
英文名称: | Olafertinib | ||||
别名: | N-(3-(2-((2,3-二氟-4-(4-(2-羟乙基)哌嗪-1-基)苯基)氨基)喹啉-8-基)苯基)丙烯酰胺 CK101; RX518;N-[3-[2-[2,3-difluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]anilino]quinazolin-8-yl]phenyl]prop-2-enamide | ||||
CAS No: | 1660963-42-7 | 分子式: | C29H28F2N6O2 | 分子量: | 530.58 |
CAS No: | 1660963-42-7 | ||||
分子式: | C29H28F2N6O2 | ||||
分子量: | 530.58 |
一种表皮生长因子(EGFR)的抑制剂。
Olafertinib, also known as CK-101 and Olafertinib, is a potent and orally active EGFR mutant-specific inhibitor. CK-101 specifically and covalently binds to and inhibits specific EGFR mutations, with particularly high selectivity against the T790M mutation; this prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some other EGFR inhibitors, CK-101 may have therapeutic benefits in tumors with T790M-mediated drug resistance.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )