磷酸奥司他韦 - CAS:204255-11-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	磷酸奥司他韦促销
英文名称:	Oseltamivir phosphate
别名:	磷酸奥司他韦 ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate;phosphoric acid
CAS No:	204255-11-8	分子式:	C₁₆H₃₁N₂O₈P	分子量:	410.40
CAS No:	204255-11-8
分子式:	C₁₆H₃₁N₂O₈P
分子量:	410.40

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O10128 磷酸奥司他韦 98% (psaitong)

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包装规格：

100mg 1g 5g in glass bottle

产品描述：

基本信息

产品编号：O10128
产品名称：Oseltamivir phosphate
CAS:	204255-11-8	储存条件	粉末	2-8℃	四年

分子式：	C16H31N2O8P		溶于液体	-80℃	两年
分子量	410.40			-20℃	一个月
化学名：	ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate phosphate
Solubility (25°C)	体外	DMSO	82mg/mL warmed with 50ºC water bath (199.8mM)
		Ethanol	Insoluble
		Water	Insoluble
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.4366mL	12.1832mL	24.3665mL
5mM	0.4873mL	2.4366mL	4.8733mL
10mM	0.2437mL	1.2183mL	2.4366mL
50mM	0.0487mL	0.2437mL	0.4873mL

生物活性

产品描述	一种神经氨酸酶抑制剂。
靶点/IC₅₀	Neuraminidase
体外研究	Oseltamivir phosphate (OP) is a prodrug that is readily absorbed from the gastrointestinal tract after oral administration and is extensively converted predominantly by hepatic esterases to Oseltamivir carboxylate (OC). Oseltamivir phosphate is a widely used anti-influenza sialidase inhibitor. The metabolic activity of CMA07 and CMT-U27 cell lines is significantly decreased with 305μM Oseltamivir phosphate treatment (p=0.005 and p<0.0001 respectively) using One Way ANOVA testes. In contrast, no statistically significant alterations are observed with 0.305μM (p=0.9781), 3.05μM (p=0.7436) and 30.5μM(p=0.9623) of Oseltamivir phosphate treatments when compare with control cells. Finally, to assess the effect of Oseltamivir phosphate on CMA07 and CMT-U27 programmed cell death, and given that 305μM Oseltamivir phosphate treatment impaired cell metabolic activity, a programmed cell death measurement is performed with the TUNEL assay. Twenty-four hour Oseltamivir phosphate treatment, specifically at 305μM, significantly increases CMA07 (p=0.001) and CMT-U27(p=0.0002) DNA fragmentation, suggesting promotion of programmed cell death, when compare with lower Oseltamivir concentrations, or with PBS.
体内研究	Oseltamivir phosphate-treated mice present significantly more inflammatory infiltrate in primary tumors (p=0.01). Ki-67 antigen and caspase-3 protein are used to assess CMT-U27 xenograft tumor cell proliferation and apoptosis respectively.Virtually no differences are found in Ki-67 and caspase 3 (p=0.2) expression between Oseltamivir-treated and non-treated mice.

推荐实验方法(仅供参考)

细胞实验:

Cell Assay

CMA07 and CMT-U27 cells are cultured in 24-well plates in triplicate for each condition: 0.305μM, 3.05μM, 30.5μM and 305μM Oseltamivir phosphate and PBS is used as control. Cells are counted every day for 7 days in a Neubauer’s chamber in a 1:2 dilution of cells in 0.4% trypan blue and cell count is done using the volume conversion factor for 1 mm3, which is 1×104.This assay is repeated 3 times and growth curves are traced.

动物实验:

Animal Administration

Mice

Female NIH(S)II-nu/nu nude mice, aged 4-6 weeks, are orthotopically inoculated with 1×106 viable CMT-U27 canine breast cancer cells in the mammary fat pad using a 25 gauge needle. A total of 8 mice are inoculated. When nodules reached a volume of approximately 500 mm3, mice (n=8) are randomized and divided into control group (n=4) and treatment group(n=4).The animals receive intraperitoneally (IP) dailly either 100μL of PBS (control group) or 100mg/Kg of Oseltamivir phosphate, diluted in PBS (treatment group) until time of death. Tumor size is measured using calipers, and tumor volume(mm3) is estimated by width×length×height.

保存条件：

2-8℃

UN码：

HazardClass：

危害声明：

安全说明：

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