| 中文名称: | OTS514 | ||||
|---|---|---|---|---|---|
| 英文名称: | OTS514 | ||||
| 别名: | (R)-9-[4-(1-氨基丙烷-2-基)苯基]-8-羟基-6-甲基噻吩并[2,3-c]喹啉-4(5H)-酮 OTS514 Hydrochloride 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one hydrochloride | ||||
| CAS No: | 1338540-63-8 | 分子式: | C21H20N2O2S.HCl | 分子量: | 400.92 |
| CAS No: | 1338540-63-8 | ||||
| 分子式: | C21H20N2O2S.HCl | ||||
| 分子量: | 400.92 | ||||
一种有效的TOPK抑制剂，IC50：2.6nM。
TS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect on small cell lung cancer. TS514 effectively suppressed growth of SCLC cell lines (IC50 ：0.4 - 42.6 nM) and led to their apoptotic cell death. Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity, which was involved in stemness of CSC. Furthermore, OTS514 treatment reduced CD90-positive SCLC cells and showed higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
