中文名称: | 那他珠单抗 | ||||
---|---|---|---|---|---|
英文名称: | Natalizumab | ||||
别名: | 那他珠单抗 Natalizumab | ||||
CAS No: | 189261-10-7 | ||||
CAS No: | 189261-10-7 |
基本信息
产品编号:N10659 |
|||||
产品名称:Natalizumab |
|||||
CAS: |
189261-10-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
分子式: |
|
溶于液体 |
-80℃ |
六个月 |
|
分子量 |
|
|
|
||
化学名: |
|
||||
Solubility (25°C) |
体外 |
DMSO |
|
||
Ethanol |
|
||||
Water |
|
||||
体内(现配现用) |
|
|
|||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一种重组的人源化单克隆抗体,与 α4β1-整联蛋白 (α4β1-integrin) 结合并阻断其与血管细胞粘附分子 1 (VCAM-1) 的相互作用。 |
靶点/IC50 |
Integrin |
体外研究 |
Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result,leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions.Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin. |
体内研究 |
Natalizumab binds rapidly and with high affinity to α4-integrin.Maximal binding (≥80% saturation), measured in vitro on isolated lymphocyte membranes, occurred 24 hours after intravenous (IV) doses of natalizumab 1mg/kg to 6mg/kg. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )