中文名称: Noradrenaline tartrate
英文名称: Noradrenaline tartrate
CAS No: 51-40-1
分子式: C8H11NO3.C4H6O6
分子量: 319.26
N10649 Noradrenaline tartrate ≥95% (psaitong)
包装规格:
1g 5g in glass bottle
产品简介:
一种天然的应激激素和神经递质,是 β1 选择性的adrenergic receptor激动剂,EC50值为 5.37 μM。
靶点:
α2-adrenergic receptor:Microbial Metabolite
α2-adrenergic receptor:Human Endogenous Metabolite
Beta-1 adrenergic receptor
体外研究:
Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA.
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保存条件:
2-8℃
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