β-d-N4-hydroxycytidine - CAS:3258-02-4 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	β-d-N4-hydroxycytidine
英文名称:	β-d-N4-hydroxycytidine
别名:	EIDD1931; N4-Hydroxycytidine
CAS No:	3258-02-4	分子式:	C₉H₁₃N₃O₆	分子量:	259.22
CAS No:	3258-02-4
分子式:	C₉H₁₃N₃O₆
分子量:	259.22

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N10186 β-d-N4-hydroxycytidine ≥98% (psaitong)

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包装规格：

1mg 5mg 10mg 25mg 50mg in glass bottle

溶解性：

溶于DMSO

产品描述：

基本信息

产品编号：N10186
产品名称：β-d-N4-hydroxycytidine
CAS:	3258-02-4	储存条件	粉末	-20℃	四年
分子式：	C9H13N3O6		溶于液体	-80℃	两年
分子量	259.22
化学名：	1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one
Solubility (25°C)	体外	DMSO
		Ethanol	3mg/mL (11.57mM)
		Water	15mg/mL (57.86mM)
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.8577mL	19.2886mL	38.5773mL
5mM	0.7715mL	3.8577mL	7.7155mL
10mM	0.3858mL	1.9289mL	3.8577mL
50mM	0.0772mL	0.3858mL	0.7715mL

生物活性

产品描述

一种有效的抗委内瑞拉马脑炎病毒剂。

靶点/IC₅₀

SARS-CoV

Enterovirus

HCV

Topoisomerase

体外研究

Beta-d-N4-hydroxycytidine is an anti-VEEV (venezuelan equine encephalitis virus) agent with EC50, EC90, and EC99 are 0.426,1.036, and 2.5μM, respectively.

Beta-d-N4-hydroxycytidine inhibits CHIKV replicon activity and the 50% effective concentration (EC50) s 0.8μM in the Huh7–CHIKV replicon cell line. Similar results is presented with the replicon in BHK-21 cells (EC50=1.8μM).

NHC has no cytotoxicity for NHC in the Huh-7 cell culture system until up to 100μM using MTT assays. The 50% cytotoxic concentration (CCsub>50) values for NHC are determined to be 30.6μM, 7.7μM, and 2.5μM in peripheral blood mononuclear(PBM), Vero, and CEM cells, respectively.

NHC behaves as a pyrimidine analog, NHC-mediated inhibition of the CHIKV replicon can be abrogated by the addition of exogenous nucleosides, such as pyrimidines C and U, but dA, dC, dG, dU, or T has no impact on the replicon. Pyrimidines A and G contributes to replicon inhibition both in the presence and in the absence of NHC.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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