| 中文名称: | NS-638 | ||||
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| 英文名称: | NS-638 | ||||
| 别名: | Calcium Channel(钙通道) NS638;2-Amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole | ||||
| CAS No: | 150493-34-8 | 分子式: | C15H11ClF3N | 分子量: | 325.72 |
| CAS No: | 150493-34-8 | ||||
| 分子式: | C15H11ClF3N | ||||
| 分子量: | 325.72 | ||||
基本信息
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产品编号： |
N10160 |
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产品名称： |
NS-638 |
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CAS: |
150493-34-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
325.72 |
-20℃ |
1个月 |
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化学名： |
2-Amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.0701mL |
15.3506mL |
30.7012mL |
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5mM |
0.6140mL |
3.0701mL |
6.1402mL |
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10mM |
0.3070mL |
1.5351mL |
3.0701mL |
生物活性
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产品描述 |
一种钙通道阻滞剂，细胞内阻断由K+激活的Ca2+浓度升高的IC50值为3.4μM。 |
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靶点 |
IC50:3.4μM (K+-stimulated intracellular Ca2+-elevation) |
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体外研究 |
NS-638 dose dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3μM,respectively.K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked with an IC50 value of 3.4μM.At this concentration no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed.NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30μM. |
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体内研究 |
In the mouse middle cerebral artery occlusion model,NS-638 administered i.p.(50mg kg-1) at 1h and 6h post-ischemia,and once a day for the next two days,results in a 48% reduction in total infarct volume.It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion. |
推荐实验方法(仅供参考)
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细胞实验: |
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The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques. |
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动物实验: |
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Mice:In the mouse middle cerebral artery occlusion model,NS-638 is administered i.p.(50mg kg-1) at 1h and 6h postischemia, and once a day for the next two days. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
