中文名称: | NLG919 (GDC-0919) 促销 | ||||
---|---|---|---|---|---|
英文名称: | NLG919 (GDC-0919) | ||||
别名: | 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol | ||||
CAS No: | 1402836-58-1 | 分子式: | C18H22N2O | 分子量: | 282.38 |
CAS No: | 1402836-58-1 | ||||
分子式: | C18H22N2O | ||||
分子量: | 282.38 |
一种具有口服活性的IDO1抑制剂,IC50:38nM,具有潜在的免疫调节和抗肿瘤活性。
NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), with potential immunomodulating and antineoplastic activities. Upon administration, NLG919 targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing tumor cells。
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )