| 中文名称: | 美加明 盐酸盐 | ||||
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| 英文名称: | Mecamylamine hydrochloride | ||||
| 别名: | 美加明盐酸盐 Inversine;N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride | ||||
| CAS No: | 826-39-1 | 分子式: | C11H21N.HCl | 分子量: | 203.75 |
| CAS No: | 826-39-1 | ||||
| 分子式: | C11H21N.HCl | ||||
| 分子量: | 203.75 | ||||
| MDL: | MFCD00151462 | EINEC: | 212-555-8 | ||
| EINEC: | 212-555-8 | ||||
基本信息
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产品编号： |
M60014 |
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产品名称： |
Mecamylamine hydrochloride |
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CAS: |
826-39-1 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃(密封储存，防潮) |
6个月 |
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分子量： |
203.75 |
-20℃(密封储存，防潮) |
1个月 |
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化学名： |
Inversine;N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
4.9080mL |
24.5399mL |
49.0798mL |
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5mM |
0.9816mL |
4.9080mL |
9.8160mL |
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10mM |
0.4908mL |
2.4540mL |
4.9080mL |
生物活性
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产品描述 |
一种一种nAChR拮抗剂。 |
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靶点 |
nAChR |
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体外研究 |
Mecamylamine blocks muscle nAChRs in a use-and voltagedependent manner.Mecamylamine blocks the nicotinic currents via trapping mechanism.The main feature of this block is the phenomenon of block relief,which might be revealed by combined action of depolarization and activation of nAChRs.The experimental study of the Mecamylamine action on muscle nAChRs revealed that:(1) Mecamylamine (1-20μM) reduces evoked end-plate currents (EPC) amplitude with Hill’s constant equal to 1.2 and IC50=7.8μM at holding potential–70 mV;(2) the calculated depth of its interaction with the muscle nAChR channel is almost half of the one of neuronal nAChRs (0.37 compare to 0.72 for neuronal nAChRs);(3) simultaneous membrane depolarization and repetitive activation of postsynaptic nAChRs by motor nerve stimulation produced rapid block relief dependent on the degree of depolarization,number of conditioning signals and Mecamylamine concentration,and only slightly depended on the rate of stimulation. |
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体内研究 |
Mecamylamine (0.5-1mg/kg;Intraperitoneal injection;C57BL/6J mice) has antidepressant-like effects in both the TST and FST and these effects are dependent on bothβ2 andα7 subunits. |
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Animal Model: |
C57BL/6J mice (3-4 months) forced swim test (FST) and tail suspension test (TST) |
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Dosage: |
0.5mg/kg,0.75mg/kg,1mg/kg |
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Administration: |
Intraperitoneal injection |
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Result: |
Significantly decreased immobility time in the TST at the 1.0-mg/kg dose but did not alter baseline locomotor activity.Also significantly decreased time immobile in the FST. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
