中文名称: | 硫酸奥西那林 | ||||
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英文名称: | Metaproterenol hemisulfate | ||||
别名: | 硫酸奥西那林 Orciprenaline hemisulfate | ||||
CAS No: | 5874-97-5 | 分子式: | C11H17NO3.0.5H2SO4 | 分子量: | 260.3 |
CAS No: | 5874-97-5 | ||||
分子式: | C11H17NO3.0.5H2SO4 | ||||
分子量: | 260.3 | ||||
EINEC: | 227-539-6 | ||||
EINEC: | 227-539-6 |
基本信息
产品编号: |
M10909 |
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产品名称: |
Metaproterenol hemisulfate |
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CAS: |
5874-97-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
260.30 |
-20℃ |
1个月 |
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化学名: |
Orciprenaline for system suitability, European Pharmacopoeia (EP) Reference Standard |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.8417mL |
19.2086mL |
38.4172mL |
5mM |
0.7683mL |
3.8417mL |
7.6834mL |
10mM |
0.3842mL |
1.9209mL |
3.8417mL |
生物活性
产品描述 |
一种直接作用的拟交感神经药,是 β2-肾上腺素能受体 (β2AR) 激动剂,其 IC50 为 68nM。Metaproterenol hemisulfate 还具有抗炎活性。 |
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靶点 |
IC50:68nM (β2-adrenergic receptor) |
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体外研究 |
Metaproterenol (10μM;74 hours;THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.Metaproterenol (10μM;74 hours;THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages. Western Blot Analysis |
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Cell Line: |
THP-1 cells and bone marrow macrophages |
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Concentration: |
10μM |
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Incubation Time: |
74 hours |
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Result: |
Enhanced β-arrestin2 and its interaction with IκBα. |
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RT-PCR |
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Cell Line: |
THP-1 cells and bone marrow macrophages |
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Concentration: |
10μM |
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Incubation Time: |
74 hours |
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Result: |
Led to downregulation of NF-κB. |
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体内研究 |
Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as proinflammatory and pro-fibrotic responses in the kidneys and heart.Thus,Metaproterenol might has protective effects against diabetic renal and cardiovascular complications. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )