MPEP HCl - CAS:219911-35-0 - CAS号查询_生物试剂_化学试剂_分析试剂_实验试剂-普西唐试剂商城

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中文名称:	MPEP HCl
英文名称:	MPEP HCl
别名:	6-甲基-2-（苯乙炔基）吡啶盐酸盐 2-Methyl-6-(phenylethynyl)pyridine hydrochloride
CAS No:	219911-35-0	分子式:	C₁₄H₁₁N^.HCl	分子量:	229.7
CAS No:	219911-35-0
分子式:	C₁₄H₁₁N^.HCl
分子量:	229.7
MDL:	MFCD02262119

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

M10327 MPEP HCl ≥98%(HPLC) (psaitong)

相关产品

包装规格：

10mg 50mg 100mg in glass bottle

溶解性：

溶于DMSO(10mg/mL)

产品描述：

基本信息

产品编号：	M10327
产品名称：	MPEP HCl
CAS:	219911-35-0	储存条件	粉末	-20℃	四年

分子式：	C14H11N.HCl		溶于液体	-80℃	6个月
分子量：	229.70			-20℃	1个月
化学名：	2-METHYL-6-(PHENYLETHYNYL)PYRIDINE,HYDROCHLORIDE
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	4.3535mL	21.7675mL	43.5350mL
5mM	0.8707mL	4.3535mL	8.7070mL
10mM	0.4354mL	2.1768mL	4.3535mL

生物活性

产品描述	一种非竞争性mGlu5受体拮抗剂，IC50:36nM。
靶点	mGluR5 36nM (IC50)
体外研究	MPEP does not show agonist or antagonist activity at 100mM on human mGlu2,-3,-4a,-7b, and -8a receptors nor at 10μM on the human mGlu6 receptor.
体内研究	MPEP (1-30mg/kg) induces anxiolytic-like effects in the conflict drinking test and the elevated plus-maze test in rats as well as in the four-plate test in mice.MPEP (1-20mg/kg) does shorten the immobility time in a tail suspension test in mice,however it is inactive in the behavioural despair test in rats.MPEP (30mg/kg i.p.) slightly but significantly increases (by 39%) the number of punished crossings in the four-plate test,lower doses of the compound (3 and 10mg/kg) does not affect the number of punished crossings in that test (F (3,36)=3.240,P<0.05).MPEP (1,10 and 20mg/kg) significantly (by 55% after the highest dose),(F(3,28)=15.47,P<0.001) decreases the immobility time of mice in the tail suspension test. Its efficacy is similar to that of imipramine (20mg/kg),used as the positive standard.
	Animal Model:	Male Wistar rats (200±250 g).
	Dosage:	IP or PO.
	Administration:	0.3,1 and 10mg/kg,i.p.(Conflict drinking test).
	Result:	At a dose of 0.3mg/kg was not ffective,at doses of 1 and 10mg/kg i.p.significantly (F (3,30)=11.193,P<0.001),increased the number of shocks (by 330 and 507%,respectively) accepted during the experimental session in the Vogel test.

	Animal Model:	Male Wistar rats (200±250g).
	Dosage:	IP or PO.
	Administration:	1,3 and 10mg/kg,i.p.or 10 and 30mg/kg,p.o.(Elevated plus-maze test).
	Result:	Administered at a dose of 1mg kg71 i.p.did not change the entries into and time spent in the open arms.At doses of 3 and 10mg/kg i.p.significantly (F (3,24)=22.978,P<0.001) dosedependently increased the time spent in the open arms (up to 45 and 74%,respectively),and the percentage of entries into the open arms (up to 48 and 68%,respectively,F(3,24)=5.678,P<.01).At doses of 3 and 10mg/kg i.p.significantly increased (by 64%) the total number of entries and reduced (by about 25%) the total timespent (data not shown) in the arms (either type).At the dose of 30mg/kg (po,but not 10mg/kg) significantly (up to 64%, F (2,16)=14.249,P<0.001) increased the percentage of the time spent in the open arms and the percentage of entries into the open arms (up to 63%,F (2,16)=7.295,P<0.01).MPEP given p.o.in both doses used did not change the total number of entries nor the total time spent in the arms (either type).

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

参考文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:		LOG(C1):
C2=C1/X	C2:		LOG(C2):
C3=C2/X	C3:		LOG(C3):
C4=C3/X	C4:		LOG(C4):
C5=C4/X	C5:		LOG(C5):
C6=C5/X	C6:		LOG(C6):
C7=C6/X	C7:		LOG(C7):
C8=C7/X	C8:		LOG(C8):

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