中文名称: MDL 29951
英文名称: MDL 29951
CAS No: 130798-51-5
分子式: C12H9Cl2NO4
分子量: 302.11
M10316 MDL 29951 ≥98%(HPLC) (psaitong)
包装规格:
5mg 25mg 100mg in glass bottle
溶解性:
溶于DMSO(≥50mg/mL)
产品描述:

基本信息

产品编号:

M10316

产品名称:

MDL 29951

CAS:

130798-51-5

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C12H9Cl2NO4

溶于液体

-80℃

6个月

分子量:

302.11

-20℃

1个月

化学名: 

2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid

Solubility (25°C):

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

3.3101mL

16.5503mL

33.1005mL

5mM

0.6620mL

3.3101mL

6.6201mL

10mM

0.3310mL

1.6550mL

3.3101mL

 

生物活性

产品描述

一种nMDA receptor拮抗剂,可抑制体内体外甘氨酸([3H]glycine)的结合,Ki值为0.14μM。

靶点

Ki:0.14μM

 

体外研究

MDL 100,748 and MDL 29,951 are approximately 2000-fold selective for the glycine binding site relative to the glutamate recognition sites.MDL-29951 is found to inhibit the human F16Bpase under these conditions (IC50=2.5μM).MDL-29951 inhibits the human liver (IC50=2.5μM),porcine kidney (IC50=1.0μM),and rabbit liver (IC50=0.21μM) isoforms of the enzyme,but is significantly less potent against the rat liver isoform (IC50=11μM).The MDL29951-activated receptor exhibits other activities associated with GPCR-mediated signaling, including G protein-dependent activation of extracellular signalregulated kinase 1 and 2 (ERK1/2) and recruitment of β-arrestin.As with recombinant cell systems,MDL29951 promotes Ca2+ signaling responses and inhibition of cyclic adenosine monophosphate (cAMP) accumulation in rat oligodendrocyte precursor cells during the period of peak GPR17 abundance.Effects of MDL29951 are markedly reduced in cells with low GPR17 abundance and are blocked by pranlukast.

 

 

推荐实验方法(仅供参考)

激酶实验:

[3H]JCPP (30.7 Ci/mmol) binding assays are conducted in minivials,incubated for 15mm at 25℃ in 1mL of 50mM Tris-HC1 (pH 7.4) containing 10nM [3H]JCPP,200g of membrane protein and unlabeled ligands as indicated.Nonspecific binding is defined using 1mM L-glutamate.Bound ligand is separated by centrifugation. Specific binding accounted for approximately 80% of total binding.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

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    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):