| 中文名称: | ML 281 | ||||
|---|---|---|---|---|---|
| 英文名称: | ML 281 | ||||
| 别名: | N-[2-(3,4-二氢-3-氧代-2-喹喔啉基)-4-(1-甲基乙基)苯基]-2-噻吩甲酰胺 ML-281 N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide | ||||
| CAS No: | 1404437-62-2 | 分子式: | C22H19N3O2S | 分子量: | 389.47 |
| CAS No: | 1404437-62-2 | ||||
| 分子式: | C22H19N3O2S | ||||
| 分子量: | 389.47 | ||||
一种有效的选择性的STK33抑制剂，IC50：14nM。与其他STK33抑制剂相比，ML281对纯化重组STK33的纳米摩尔抑制作用较低，选择性明显。
ML-281 is a potent ans selective STK33 inhibitor (IC50 = 14 nM). ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. ML281 is a valuable addition to small-molecule probes of STK33. v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors. STK33 was selectively toxic to KRAS-dependent cancer cell lines, suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
