氯沙坦钾 - CAS:124750-99-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	氯沙坦钾促销
英文名称:	Losartan potassium
别名:	(1-((2'-(2H-四唑-5-基)-[1,1'-联苯]-4-基)甲基)-2-丁基-4-氯-1H-咪唑基-5-基)甲基醇单钾 DuP-753 potassium
CAS No:	124750-99-8	分子式:	C₂₂H₂₂ClKN₆O	分子量:	461
CAS No:	124750-99-8
分子式:	C₂₂H₂₂ClKN₆O
分子量:	461
MDL:	MFCD02092704

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L10419 氯沙坦钾 ≥98% (psaitong)

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包装规格：

100g in glass bottle

溶解性：

溶于水（20mg/mL），溶于DMSO（≥50mg/mL）

产品描述：

基本信息

产品编号：	L10419
产品名称：	Losartan potassium
CAS:	124750-99-8	储存条件	粉末	室温	四年

分子式：	C22H22ClKN6O		溶于液体	-80℃	6个月
分子量：	461.00			-20℃	1个月
化学名：	potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Solubility (25°C)：
体外:	DMSO	92mg/mL (199.12mM)
	Ethanol	92mg/mL (199.12mM)
	Water	92mg/mL (199.12mM)
体内(现配现用):	Saline	30mg/mL
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.1645mL	10.8223mL	21.6446mL
5mM	0.4329mL	2.1645mL	4.3289mL
10mM	0.2164mL	1.0822mL	2.1645mL
50mM	0.0433mL	0.2164mL	0.4329mL

生物活性

产品描述	一种血管紧张素 II 受体 1 型 (AT1)拮抗剂，与血管紧张素 II 与 AT1 的结合竞争，IC50 为 20nM。
靶点	AT1 receptor
靶点	20nM
体外研究	Losartan competes with the binding of angiotensin II to AT1 receptors.The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20nM.Losartan (40μM) affects ISC but prevents the effect of ANGII on ISC.Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells.The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone.
体内研究	Losartan (0.6g/L,p.o.) -treated Fbn1C1039G/+mice show a reduction in distal airspace caliber relative to placebo-treated Fbn1C1039G/+animals.The doses of losartan and propranolol are titrated to achieve comparable hemodynamic effects.Analysis of pSmad2 nuclear staining reveals that losartan antagonizes TGF-β signaling in the aortic wall of Fbn1C1039G/+mice.Losartan can improve disease manifestations in the lungs,an event that cannot plausibly relate to improved hemodynamics.Losartan (10mg/kg,intraarterial injection) increases blood angiotensin levels four- to sixfold.Losartan (10mg/kg,i.p.) increases plasma renin levels 100-fold;plasma angiotensinogen levels decreases to 24% of control;and plasma aldosterone levels are unchanged.

推荐实验方法(仅供参考)

细胞实验:

An MTT assay is used to measure cell proliferation and viability.For the assay,5000 cells in 200μL media per well are seeded in a 96 well plate.After overnight incubation to allow for cell attachment,the medium is removed by suction.MTT at 1mg/mL concentration in serum-free medium is added and then incubated for 4 h at 37℃.After removal of MTT solution,100μL of DMSO is added to dissolve formazan crystals.Absorbance at 570nm and at 600nm as a reference is then measured using a microplate reader.The difference in absorbance is thus relative to the extent of cell survival.

动物实验:

Female Fbn1C1039G/+mice undergo timed matings with wild-type male mice.At 14.5d post-coitum,pregnant female Fbn1 C1039G/+mice are treated with oral losartan (0.6g/L in drinking water;n=10),propranolol (0.5g/L;n=6) or placebo (n=12).Therapy is continued throughout lactation and after weaning until 10 months of age.Mice are sacrificed and examined using the techniques described above.Propranolol is used for comparison with losartan because β-adrenergic receptor blockade is the current albeit controversial standard of care to modulate abnormal growth of the aortic root in MFS.Beginning at 7 weeks of age,wild-type and Fbn1C1039G/+mice are treated with oral losartan (0.6g/L in drinking water;n=5),propranolol (0.5g/L;n=7) or placebo (n=10).Mice are continued on oral therapy for 6 months and then sacrificed.

保存条件：

室温

UN码：

HazardClass：

危害声明：

安全说明：

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