基本信息
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产品编号： |
L10319 |
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产品名称： |
Lidocaine |
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CAS: |
137-58-6 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃(避光) |
6个月 |
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分子量： |
234.34 |
-20℃(避光) |
1个月 |
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化学名： |
Lidocaine solution,1.0mg/mL in methanol,ampule of 1mL,certified reference material |
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Solubility (25°C)： |
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体外:
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DMSO |
47mg/mL (200.56mM) |
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Ethanol |
47mg/mL (200.56mM) |
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Water |
9mg/mL (38.4mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
4.2673mL |
21.3365mL |
42.6730mL |
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5mM |
0.8535mL |
4.2673mL |
8.5346mL |
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10mM |
0.4267mL |
2.1337mL |
4.2673mL |
生物活性
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产品描述 |
可抑制涉及复杂电压和依赖性的钠通道,通过调节miR-145表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长，迁移和侵袭。 |
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靶点 |
MEK |
ERK |
NF-κB |
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体外研究 |
Lidocaine (Lignocaine) (10nM;48 hours) decreases significantly cell proliferation.Lidocaine (1-10nM;24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10nM and treatment time 48 hours.Lidocaine (10nM;48 hours) increases significantly the apoptotic cell rate.Lidocaine (10nM;48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly. Cell Proliferation Assay |
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Cell Line: |
The human gastric cancer cell line MKN45 |
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Concentration: |
10nM |
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Incubation Time: |
48 hours |
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Result: |
Decreased significantly cell proliferation. |
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Cell Viability Assay |
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Cell Line: |
The human gastric cancer cell line MKN45 |
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Concentration: |
1,5 and 10nM |
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Incubation Time: |
24,48,72 hours |
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Result: |
Inhibited MKN45 cell viability. |
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Apoptosis Analysis |
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Cell Line |
The human gastric cancer cell line MKN45 |
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Concentration: |
10nM |
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Incubation Time: |
48 hours |
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Result: |
Increased significantly the apoptotic cell rate. |
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Western Blot Analysis |
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Cell Line: |
The human gastric cancer cell line MKN45 |
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Concentration: |
10nM |
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Incubation Time: |
48 hours |
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Result: |
Down-regulated Cyclin D1 and up-regulated p21 expression significantly. |
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体内研究 |
Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats.Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
