中文名称: | Lupiwighteone | ||||
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英文名称: | Lupiwighteone | ||||
别名: | 黄羽扇豆魏特酮;5,7-二羟基-3-(4-羟基苯基)-8-(3-甲基-2-丁烯)-4H-1-苯并吡喃-4-酮 5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 8-Prenylgenistein | ||||
CAS No: | 104691-86-3 | 分子式: | C20H18O5 | 分子量: | 338.4 |
CAS No: | 104691-86-3 | ||||
分子式: | C20H18O5 | ||||
分子量: | 338.4 |
基本信息
产品编号: |
L10250 |
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产品名称: |
Lupiwighteone |
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CAS: |
104691-86-3 |
储存条件 |
粉末 |
2-8℃ |
四年 |
分子式: |
溶于液体 |
-80℃(避光) |
6个月 |
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分子量: |
338.40 |
-20℃(避光) |
1个月 |
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化学名: |
5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;8-Prenylgenistein |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
Lupiwighteone是一种广泛存在于野生植物中的异黄酮,具有抗氧化、抗菌和抗癌作用。Lupiwighteone通过抑制PI3K/Akt/mTOR通路,诱导人乳腺癌细胞caspase依赖性和非依赖性凋亡(apoptosis)。 |
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靶点 |
apoptosis |
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体外研究 |
Lupiwighteone (2-100μM;72 hours) shows cytotoxicity towards various cell lines,especially on DU-145 cells and SGC-7901 cells with IC50s of 23.7μM and 21μM,respectively.Lupiwighteone (20-60μM;48 hours) induces (cell cycle arrest in DU-145 cells.Lupiwighteone (20-60μM;48 hours) induces cells apoptosis.Lupiwighteone (20-60μM;48 hours) decreases the cell cycle-related protein expressions in a dose-dependent manner in DU145 cells.Lupiwighteone (20-60μM;48 hours) induces a dose-dependent increase in ROS production.Lupiwighteone up-regulates of cytochrome c and caspase-3,and subsequent cleavage of PARP-1 and down-regulates of the p-Akt/Akt ratio and VEGF expression,suggests the activation of mitochondria-based intrinsic apoptosis in DU-145 cells. Cell Viability Assay |
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Cell Line: |
DU-145 cells,C4-2 cells,SGC-7901 cells,Hela cells,HUVEC,MCF-7 cells,CNE cells,Vero |
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Concentration: |
2μM,5μM,25μM,50μM,100μM |
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Incubation Time: |
72 hours |
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Result: |
Had inhibition on the survival of many cancer cell lines and HUVEC. |
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Cell Cycle Analysis |
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Cell Line: |
DU-145 cells |
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Concentration: |
20μM,40μM,60μM |
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Incubation Time: |
48 hours |
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Result: |
Induced cell cycle arrest. |
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Apoptosis Analysis |
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Cell Line: |
DU-145 cells |
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Concentration: |
20μM,40μM,60μM |
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Incubation Time: |
48 hours |
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Result: |
Induced apoptosis. |
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Western Blot Analysis |
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Cell Line: |
DU-145 cells |
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Concentration: |
20μM,40μM,60μM |
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Incubation Time: |
48 hours |
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Result: |
Decreased CDK1,2,4,6,cyclinD1,and cyclinB1 protein expression in a dose-dependent manner. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )