| 中文名称: | LU AE58054（Idalopirdine) | ||||
|---|---|---|---|---|---|
| 英文名称: | LU AE58054（Idalopirdine) | ||||
| 别名: | LU AE58054（Idalopirdine) (2-(6-fluoro-1H-indol-3-yl)-ethyl)-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)amine | ||||
| CAS No: | 467459-31-0 | 分子式: | C20H19F5N2O | 分子量: | 398.38 |
| CAS No: | 467459-31-0 | ||||
| 分子式: | C20H19F5N2O | ||||
| 分子量: | 398.38 | ||||
一种有效的选择性的5-HT6受体拮抗剂，Ki：0.83nm。
LU AE58054 is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. It is in phase III clinical trials. Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. Lu AE58054 demonstrated >50-fold selectivity for more than 70 targets examined. Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Lu AE58054 may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease。
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
