| 中文名称: | KC7F2 | ||||
|---|---|---|---|---|---|
| 英文名称: | KC7F2 | ||||
| 别名: | HIF/HIF Prolyl-Hydroxylase N,N'-(disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide) | ||||
| CAS No: | 927822-86-4 | 分子式: | C16H16Cl4N2O4S4 | 分子量: | 570.35 |
| CAS No: | 927822-86-4 | ||||
| 分子式: | C16H16Cl4N2O4S4 | ||||
| 分子量: | 570.35 | ||||
一种有效的缺氧诱导因子HIF-1通道抑制剂，在LN229-HRE-AP细胞中IC50:20μM。
KC7F2 is a potent HIF-1 pathway inhibitor with potential anticancer activity. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 ?M. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), endothelin 1, and enolase 1. KC7F2 worked through the down-regulation of HIF-1alpha protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1alpha protein synthesis.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
