| 中文名称: | JZP-430 | ||||
|---|---|---|---|---|---|
| 英文名称: | JZP-430 | ||||
| 别名: | JZP-430 4-Morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate | ||||
| CAS No: | 1672691-74-5 | 分子式: | C16H26N4O3S | 分子量: | 354.47 |
| CAS No: | 1672691-74-5 | ||||
| 分子式: | C16H26N4O3S | ||||
| 分子量: | 354.47 | ||||
一种有效的、高度选择性的、不可逆的α/β水解酶结构域6(ABHD6)抑制剂，靶向抑制人类ABHD6的IC50值为44nM。
JZP-430 is a potent and selective ABHD6 inhibitor. P-430 potently and irreversibly inhibited hABHD6 (IC50 =44 nM) and showed ∼230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds. Additionally, activity-based protein profiling indicated that JZP-430 displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. JZP-430 has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
