中文名称: | Indisulam | ||||
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英文名称: | Indisulam | ||||
别名: | N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺 E7070 | ||||
CAS No: | 165668-41-7 | 分子式: | C14H12ClN3O4S2 | 分子量: | 385.85 |
CAS No: | 165668-41-7 | ||||
分子式: | C14H12ClN3O4S2 | ||||
分子量: | 385.85 |
一种碳酸酐酶抑制剂,具有抗癌活性。Indisulam(E7070)是细胞周期G1期的靶向化合物。Indisulam(E7070)通过抑制CDK2和周期蛋白E的激活,引起G1/S转化被阻滞。Indisulam(E7070)通过募集DCAF15诱导RBM39降解来靶向剪接。
Indisulam, also known as E7070, is a carbonic anhydrase inhbitor, is also a novel synthetic sulfonamide that targets the G1 phase of the cell cycle.. The potential antitumor activity of Indisulam was discovered through optimization of the structure-activity relationships of a series of sulfonamide structures. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E. Preclinical studies with Indisulam showed activity in multiple tumor types, most prominently in colon and lung cancer.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )